Hydrolyzed collagen
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Hydrolyzed Collagen: Sources, Applications, and Health Benefits
Introduction to Hydrolyzed Collagen
Hydrolyzed collagen (HC) is a group of peptides with low molecular weight (3-6 KDa) obtained through enzymatic hydrolysis in acid or alkaline media at specific temperatures. HC can be derived from various sources, including bovine, porcine, and marine sources such as fish skin, scales, and bones. The type and source of extraction significantly influence HC properties, including molecular weight, solubility, and functional activity. HC is utilized across multiple industries, including food, pharmaceuticals, cosmetics, biomedicine, and leather1.
Health Benefits of Hydrolyzed Collagen
Skin Health and Anti-Aging
Hydrolyzed collagen has been extensively studied for its benefits on skin health. Clinical trials have shown that ingestion of collagen hydrolysates, particularly those rich in bioactive peptides like prolyl-hydroxyproline (Pro-Hyp) and hydroxyprolyl-glycine (Hyp-Gly), significantly improves skin moisture, elasticity, and reduces wrinkles and roughness. These peptides enhance dermal fibroblast activity, promoting hyaluronic acid production and cell proliferation, which are crucial for maintaining youthful skin2 4 5.
Joint Health and Pain Relief
Collagen is rich in amino acids such as glycine, proline, and hydroxyproline, which are essential for joint health. Studies have demonstrated that hydrolyzed collagen can alleviate joint pain associated with osteoarthritis and physical activity by improving the bioavailability and absorption rate of these amino acids. Enzymatically hydrolyzed collagen has shown higher absorption rates and bioavailability compared to non-hydrolyzed forms, making it more effective in reducing joint pain3.
Bone Health and Osteoporosis
Hydrolyzed collagen has also been shown to positively impact bone metabolism, particularly in the context of osteoporosis. In animal studies, dietary supplementation with hydrolyzed collagen increased bone mineral density (BMD) and bone strength, while reducing bone resorption markers. This suggests that HC can enhance osteoblast activity and bone remodeling, making it a potential therapeutic option for osteoporosis6.
Applications in Food and Beverages
Hydrolyzed collagen is increasingly being incorporated into functional foods and beverages. For instance, fruit juice drinks containing hydrolyzed fish collagen have been developed, offering enhanced protein content and bioavailability. These drinks not only provide nutritional benefits but also improve sensory attributes, making them a popular choice among consumers9.
Biomedical and Cosmetic Applications
In the biomedical field, hydrolyzed collagen is used in wound care dressings due to its ability to improve wound healing. HC-based dressings enhance wound inflammation resolution, perfusion, and the breaking strength of repaired tissue, making them effective in clinical wound management10. In cosmetics, HC is used in formulations aimed at improving skin hydration, elasticity, and reducing the appearance of wrinkles4.
Conclusion
Hydrolyzed collagen is a versatile biomaterial with a wide range of applications in various industries. Its health benefits, particularly for skin, joint, and bone health, are well-documented, making it a valuable supplement for improving overall well-being. As research continues, the potential applications and benefits of hydrolyzed collagen are likely to expand, further solidifying its role in health and wellness.
Sources and full results
Most relevant research papers on this topic
Hydrolyzed Collagen—Sources and Applications
Hydrolyzed collagen, extracted from marine sources, has promising properties and applications in various industries, such as food, pharmaceutical, cosmetic, biomedical, and leather.
Highly CitedIngestion of bioactive collagen hydrolysates enhance facial skin moisture and elasticity and reduce facial ageing signs in a randomised double-blind placebo-controlled clinical study.
Collagen hydrolysates with higher content of bioactive collagen peptides significantly improve facial skin moisture, elasticity, wrinkles, and roughness compared to placebo.
RCT
Rigorous JournalHighly CitedEnzymatic Hydrolysis of a Collagen Hydrolysate Enhances Postprandial Absorption Rate—A Randomized Controlled Trial
Enzymatic hydrolysis of collagen hydrolysates enhances the absorption rate and bioavailability of collagen-rich amino acids glycine, proline, and hydroxyproline, potentially benefiting joint pain and osteoarthritis treatment.
RCT
Very Rigorous JournalEvaluation of the Efficacy of a Hydrolyzed Collagen Supplement for Improving Skin Moisturization, Smoothness, and Wrinkles.
Hydrolyzed collagen supplementation improves skin moisturization, elasticity, and wrinkle depth after 28 days, with no adverse effects observed.
RCTEffects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta‐analysis
Hydrolyzed collagen supplementation for 90 days effectively reduces skin aging by improving hydration, elasticity, and wrinkles.
Meta-AnalysisHydrolyzed collagen improves bone metabolism and biomechanical parameters in ovariectomized mice: an in vitro and in vivo study.
Hydrolyzed collagen improves bone metabolism and biomechanical parameters in ovariectomized mice, potentially benefiting osteoporosis treatment.
Rigorous JournalHighly CitedSequential extraction of gel-forming proteins, collagen and collagen hydrolysate from gutted silver carp (Hypophthalmichthys molitrix), a biorefinery approach.
Sequential hydrolysis of gutted silver carp residue can produce high-quality collagen and collagen hydrolysate, offering a promising basis for a multiple-product fish biorefinery.
Highly CitedTransepithelial transport efficiency of bovine collagen hydrolysates in a human Caco-2 cell line model.
Alcalase/Flavourzyme combination hydrolyzed bovine collagen effectively improves transepithelial transport efficiency, offering greater resistance to gastrointestinal digestion and greater resistance to GI digestion than unhydrolyzed collagen.
Fruit juice drink production containing hydrolyzed collagen
The most preferred fruit juice drink formulation, containing 2.5% hydrolyzed collagen, is orange, apple, and white grape juice blends, with orange and apple drinks showing higher bioavailability.
Highly CitedHydrolyzed Collagen Powder Dressing Improves Wound Inflammation, Perfusion and Breaking Strength of Repaired Tissue.
Hydrolyzed collagen powder dressings improve wound inflammation, perfusion, and healing quality, potentially reducing recurrences in closed wounds.
Non-RCT
Animal Study