Ibuprofen 200mg dosage
Pro Research Analysisby 
Searched over 200M research papers
Ibuprofen 200mg Dosage: Efficacy and Pharmacokinetics
Analgesic Efficacy of Ibuprofen 200mg
Ibuprofen, a widely used non-steroidal anti-inflammatory drug (NSAID), is effective in managing acute and chronic pain conditions. Studies have shown that a single dose of 200mg ibuprofen provides significant pain relief for various types of pain, including postoperative pain and dental pain . In a comprehensive review of 72 studies involving 9186 participants, ibuprofen 200mg was found to provide at least 50% pain relief in 46% of participants, with a number-needed-to-treat-to-benefit (NNT) of 2.7. This indicates that ibuprofen 200mg is a reliable option for moderate to severe pain relief.
Dose-Response Relationship
The analgesic efficacy of ibuprofen demonstrates a dose-response relationship. A study involving 304 patients undergoing third molar surgery showed that while 50mg and 100mg doses provided some pain relief, the 200mg dose was significantly more effective. This dose-response relationship was further supported by another study comparing ibuprofen doses of 100mg, 200mg, and 400mg, where the 200mg dose was found to be more effective than the 100mg dose but less effective than the 400mg dose.
Pharmacokinetics of Ibuprofen 200mg
The pharmacokinetic properties of ibuprofen 200mg have been well-studied. In a randomized crossover study, two over-the-counter 200mg ibuprofen preparations were compared, showing that both preparations had similar bioavailability, although one preparation achieved peak plasma concentration faster than the other. Rapid absorption and high plasma concentrations are desirable for acute pain management, making ibuprofen 200mg a suitable choice for quick relief.
Comparative Efficacy with Other Analgesics
Ibuprofen 200mg has been compared with other analgesics in various studies. For instance, a study comparing ibuprofen 200mg with aspirin 650mg found that ibuprofen provided superior pain relief and required less frequent remedication. Additionally, ibuprofen 200mg combined with other analgesics, such as codeine or caffeine, has shown enhanced efficacy for postoperative pain management .
Safety and Adverse Effects
Ibuprofen 200mg is generally well-tolerated, with adverse events being uncommon and not significantly different from placebo. Mild transient adverse events were reported in a small percentage of patients, but there was no significant difference in the frequency of these events between different doses of ibuprofen and placebo.
Conclusion
Ibuprofen 200mg is an effective and well-tolerated option for managing moderate to severe pain. Its analgesic efficacy, favorable pharmacokinetic profile, and safety make it a reliable choice for both acute and chronic pain conditions. The dose-response relationship further supports its use, with 200mg providing significant pain relief while maintaining a good safety profile.
Sources and full results
Most relevant research papers on this topic