Ibuprofen brands
Pro Research Analysisby 
Searched over 200M research papers for "ibuprofen brands"
Comparative Analysis of Ibuprofen Brands
Patient-Reported Outcomes and Efficacy
Efficacy of Different Ibuprofen Brands for Pain Relief
A study comparing two brands of 400 mg ibuprofen for musculoskeletal pain relief found that Brand B was consistently rated higher than Brand A across several measures. Participants reported better pain alleviation, higher medication efficacy, and a greater positive impact on quality of life with Brand B1. This suggests that while both brands are legally equivalent, they are not clinically equivalent, with Brand B being more effective in most parameters evaluated.
Impact of Branding on Perceived Effectiveness
Research has shown that branding significantly influences the perceived effectiveness of ibuprofen. In a study where participants were given either branded "Nurofen" or generic ibuprofen, the branded tablets, even when they were placebos, were reported to be more effective than the generic-labeled placebos. This indicates that branding can enhance the perceived efficacy of a medication, even in the absence of an active ingredient2.
Pharmacokinetics and Bioequivalence
Bioequivalence of Generic and Branded Ibuprofen
A pharmacokinetic study comparing a generic formulation and a branded formulation of 0.2 g ibuprofen granules found that both formulations were bioequivalent in healthy Chinese participants under fasting and fed conditions. The primary pharmacokinetic parameters, such as Cmax and AUC, were within acceptable limits for both formulations, indicating that the generic version is a viable alternative to the branded one3.
Pharmaceutical Quality and Market Variability
Quality Evaluation of Ibuprofen Tablets
Several studies have evaluated the pharmaceutical quality of different ibuprofen brands. In Kosovo, three commonly used ibuprofen formulations were tested for weight uniformity, disintegration time, friability, and active content. All brands met the official specifications, indicating good quality control4. Similarly, an analysis of ten brands in Nigeria revealed variability in pharmaceutical quality, with some brands failing the content of active ingredient tests using UV methods but passing with HPLC5.
Substandard and Falsified Products
In developing countries like Georgia, where substandard and falsified medical products are a concern, a study of ten ibuprofen brands found that all contained the labeled amounts of the active pharmaceutical ingredient (API). This suggests that, at least for ibuprofen, the quality control measures in place are effective6.
Clinical Effectiveness in Specific Conditions
Ibuprofen for Patent Ductus Arteriosus (PDA) Closure
A clinical trial comparing two brands of ibuprofen for PDA closure in preterm neonates found that the brand Pedea was more effective than a generic ibuprofen brand. Pedea had a higher rate of PDA closure and reduced the need for surgical intervention, highlighting the importance of brand selection in specific clinical scenarios7.
Conclusion
The effectiveness and quality of ibuprofen can vary significantly between brands. While some generic formulations are bioequivalent to their branded counterparts, patient-reported outcomes and clinical effectiveness can differ. Branding also plays a crucial role in perceived medication efficacy. Therefore, both healthcare providers and patients should consider these factors when selecting an ibuprofen brand for treatment.
Sources and full results
Most relevant research papers on this topic
Patient-reported outcomes of therapy with two brands of ibuprofen
Brand B of 400 mg ibuprofen is rated more efficacious than brand A, despite being legally pharmaceutical equivalent, influencing patients' preferences and demand in the Nigerian community.
RCTImpact of brand or generic labeling on medication effectiveness and side effects.
Brand name medication labels are associated with increased medication effectiveness and reduced side effects compared to generic labels.
RCTPharmacokinetics, Bioequivalence, and Safety Evaluation of Two Formulations of 0.2‐g Ibuprofen Granules
Two formulations of 0.2-g ibuprofen granules were found to be bioequivalent in healthy Chinese volunteers under both fasting and fed conditions.
RCT
Very Rigorous JournalIn vitro Pharmaceutical Quality Evaluation of different Ibuprofen tablet brands available on the Republic of Kosovo Market
Ibuprofen tablets tested in this study meet official specifications, are chemically equivalent, and do not vary in physiochemical qualities.
A comparative UV−HPLC analysis of ten brands of ibuprofen tablets
Ibuprofen (400 mg) tablets marketed in Benin City, Nigeria vary in pharmaceutical quality, with two brands failing the UV method of assay but all passing the HPLC test.
Comparative Analysis of Different Brands of Ibuprofen available on the Georgian Pharmaceutical Market
All brand ibuprofens on the Georgian pharmaceutical market, including Motrin and Advil, contained labeled amounts of Active Pharmaceutical Ingredient (API).
Evaluating the Effectiveness of Ibuprofen from 2 Different Brands in Patent Ductus Arteriosus Closure in Preterm Neonates
Pedea is more effective than Ibuprofen in patent ductus arteriosus closure in premature neonates, reducing complications and the need for surgery, with no significant relationship based on PDA sizes.
Non-prescription (OTC) oral analgesics for acute pain - an overview of Cochrane reviews.
Combinations of ibuprofen and paracetamol are the most effective non-prescription analgesics for acute postoperative pain, with success rates of 70% and lower adverse event rates.
Systematic ReviewVery Rigorous Journal
Highly CitedIn-vitro evaluation of the pharmaceutical quality of some ibuprofen tablets dispensed in Nigeria
Ibuprofen tablets dispensed in Nigeria vary significantly in pharmaceutical quality, requiring strict checks by regulatory agencies and distributors before public distribution.
In Vitro Study