10 papers analyzed
These studies suggest that reliable biomarkers for chronic exposure to multiple anthropogenic pollutants include polycyclic aromatic hydrocarbons, volatile organic carbons, protein expression changes, molecular signatures, miRNA profiles, and epigenetic markers.
The identification of reliable biomarkers for chronic exposure to multiple anthropogenic pollutants is crucial for assessing environmental health risks and implementing regulatory measures. Biomarkers can provide early warning signals of adverse biological responses, even at low pollutant concentrations, and help in understanding the mechanisms of toxicity.
Oxidative Stress and DNA Damage Biomarkers:
Immune and Inflammatory Responses:
Neuroendocrine and Histological Biomarkers:
Proteomic and Transcriptomic Biomarkers:
Epigenetic Biomarkers:
Lipidomic Biomarkers:
Circulating miRNAs:
Computational Methods for Biomarker Discovery:
The identification of reliable biomarkers for chronic exposure to multiple anthropogenic pollutants involves a multi-faceted approach, incorporating oxidative stress and DNA damage markers, immune and inflammatory responses, neuroendocrine and histological changes, proteomic and transcriptomic analyses, epigenetic modifications, lipidomic profiles, and circulating miRNAs. Advanced computational methods enhance the discovery and validation of these biomarkers, providing valuable tools for environmental health risk assessment and regulatory purposes.
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