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Some studies suggest that increased porosity enhances cancer cell proliferation and dissemination, while other studies indicate that higher porosity can reduce cell growth and promote differentiation.
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The influence of porosity on cancer cells is a critical area of research, as the microenvironment, including the extracellular matrix (ECM) properties, significantly affects cancer cell behavior. This synthesis aims to consolidate findings from various studies to understand how porosity impacts cancer cell proliferation, adhesion, differentiation, and overall behavior.
Enhanced Proliferation with Increased Porosity and Stiffness:
Porosity and Cell Adhesion:
Porosity and Differentiation:
Porosity and Tumor Growth:
Cell Cycle and Pore Penetration:
The porosity of the extracellular matrix and other scaffolding materials plays a significant role in cancer cell behavior. Increased porosity generally enhances cancer cell proliferation, adhesion, and initial metabolic activities. Over time, higher porosity also promotes differentiation, indicating a complex relationship between the microenvironment and cancer cell dynamics. Understanding these interactions can inform the development of therapeutic strategies targeting the tumor microenvironment.
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