Iron supplement that doesn't cause constipation
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Summary
9 papers analyzed
These studies suggest that low-dose or intermittent iron supplements, such as Hemofer, ULT, and PregVit®, are less likely to cause constipation compared to traditional high-dose iron supplements.
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Iron Supplements That Don't Cause Constipation
Iron deficiency is a common health issue, particularly among premenopausal women and individuals with anemia. While iron supplements are a standard treatment, they often come with gastrointestinal side effects, including constipation. This article explores various iron supplements that minimize these side effects, based on recent research findings.
Low-Dose Iron Supplements: Effective and Gentle
Low-Dose Liquid Fermented Iron-Bisglycinate Supplement (LIS)
A study on premenopausal women with iron deficiency without anemia (IDWA) found that a low-dose liquid fermented iron-bisglycinate supplement (LIS) significantly improved blood-iron status without causing gastrointestinal distress, including constipation. Over an 8-week period, participants taking LIS showed increased serum ferritin and total serum iron levels compared to a placebo group, with no significant increase in gastrointestinal side effects.
Heme Iron vs. Non-Heme Iron
Research comparing heme iron and non-heme iron supplements in blood donors revealed that heme iron supplements are better tolerated. Participants taking a combination of heme and non-heme iron (Hemofer) reported fewer instances of constipation and other gastrointestinal side effects compared to those taking only non-heme iron (Erco-Fer).
Novel Iron Sources: Aspergillus Oryzae
Iron-Enriched Aspergillus Oryzae (ULT)
A study comparing traditional ferrous sulfate (FeSO4) with iron-enriched Aspergillus oryzae (ULT) found that ULT had fewer gastrointestinal side effects. Participants taking ULT reported less abdominal discomfort and a lower incidence of constipation, nausea, and diarrhea compared to those taking FeSO4. Compliance was also higher with ULT, suggesting it is a safer and more tolerable option for iron supplementation.
Intermittent Iron Supplementation: A Safer Alternative
Intermittent vs. Daily Supplementation
Intermittent iron supplementation, where iron is taken one to three times a week instead of daily, has been shown to reduce the risk of gastrointestinal side effects, including constipation. Studies indicate that intermittent supplementation is nearly as effective as daily supplementation in improving hemoglobin and ferritin levels, but with fewer adverse effects .
Mechanisms Behind Gastrointestinal Side Effects
Methanogenesis and Constipation
Research has linked oral iron supplementation to increased methane production in the gut, which can slow intestinal transit and cause constipation. Methane production is driven by methanogenic archaea, which require iron for their metabolic processes. This connection suggests that reducing iron exposure in the gut could mitigate these side effects .
Conclusion
For individuals seeking iron supplements that do not cause constipation, low-dose options like liquid fermented iron-bisglycinate, heme iron supplements, and iron-enriched Aspergillus oryzae are promising alternatives. Additionally, intermittent iron supplementation can effectively manage iron levels while minimizing gastrointestinal distress. Understanding the mechanisms behind these side effects can further guide the development of more tolerable iron supplements.
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