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These studies suggest that iron supplementation, whether intermittent or daily, can effectively reduce anaemia and improve iron levels in various populations, but the optimal regimen may vary depending on the specific health condition and population, with considerations for potential side effects and absorption differences.
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Iron supplements are commonly used to prevent and treat iron deficiency and anemia. They come in various forms and are administered through different regimens, including daily, intermittent, and intravenous methods. This article explores the names of iron supplements and their efficacy based on recent research.
Ferrous sulfate is one of the most widely used iron supplements. It is available in both sustained-release and immediate-release formulations. Studies have shown that ferrous sulfate can effectively improve iron status and reduce anemia in various populations, including pregnant women and children .
Ferrous gluconate and ferrous fumarate are other common forms of iron supplements. These are often used as alternatives to ferrous sulfate, especially for individuals who experience gastrointestinal side effects from ferrous sulfate .
Iron polysaccharide complex is another form of iron supplement that is designed to reduce gastrointestinal side effects. It is often recommended for individuals who cannot tolerate other forms of iron.
For patients with chronic kidney disease (CKD) or those who cannot absorb oral iron effectively, intravenous (IV) iron supplements such as iron sucrose and ferric carboxymaltose are commonly used. These forms are particularly effective in rapidly increasing hemoglobin levels.
Daily iron supplementation is the traditional approach for treating iron deficiency and anemia. It has been shown to significantly reduce maternal anemia and iron deficiency during pregnancy, as well as improve birth outcomes . However, daily supplementation is often associated with side effects such as nausea, constipation, and teeth staining, which can affect adherence .
Intermittent iron supplementation, where iron is taken one to three times a week, has been proposed as a safer and equally effective alternative to daily supplementation. Research indicates that intermittent supplementation can reduce the risk of anemia and improve hemoglobin and ferritin levels, with fewer side effects compared to daily regimens . This regimen is particularly beneficial in settings where daily supplementation is not feasible due to side effects or supply issues .
IV iron supplementation is preferred for patients with CKD, especially those on dialysis. Studies have shown that IV iron is more effective than oral iron in increasing hemoglobin levels and is associated with fewer gastrointestinal side effects, although it carries a higher risk of hypotension.
Iron supplementation in iron-deficient non-anemic (IDNA) athletes is a growing trend. Some studies suggest that iron supplementation can improve performance in athletes with low ferritin levels (<20 µg/L), although the evidence is mixed.
Daily iron supplementation in children aged 4-23 months has been shown to reduce the risk of anemia and iron deficiency. However, the impact on growth and development is less clear, and there are concerns about adverse effects such as vomiting and fever.
Iron supplements, including ferrous sulfate, ferrous gluconate, ferrous fumarate, and iron polysaccharide complex, are effective in treating and preventing iron deficiency and anemia. The choice of supplement and regimen—daily, intermittent, or intravenous—depends on the individual's needs, tolerance, and specific health conditions. While daily supplementation is effective, intermittent and intravenous regimens offer viable alternatives with potentially fewer side effects. Further research is needed to optimize iron supplementation strategies for different populations.
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