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Some studies suggest ketogenic diets may help prevent cancer by reducing tumor growth and enhancing treatment effects, while other studies indicate no conclusive evidence for anti-tumor effects or improved survival.
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The ketogenic diet (KD), characterized by high fat and low carbohydrate intake, has been proposed as a potential therapeutic strategy for cancer. This diet alters metabolism by inducing ketosis, which may create an unfavorable environment for cancer cells. This synthesis aims to evaluate the evidence on whether a ketogenic diet can prevent cancer.
Metabolic Environment and Tumor Sensitization:
Preclinical Evidence:
Clinical Evidence and Safety:
Mechanisms of Action:
While preclinical studies provide promising evidence that a ketogenic diet can inhibit tumor growth and enhance the efficacy of standard cancer therapies, clinical evidence remains inconclusive. KD appears to be safe and may improve quality of life by reducing body weight and fat mass in cancer patients. However, more high-quality, large-scale clinical trials are needed to definitively determine the effectiveness of KD in cancer prevention and treatment.
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