Lisino 5mg
Pro Research Analysisby 
Searched over 200M research papers for "lisino 5mg"
Consensus Meter
Lisinopril 5mg: Efficacy, Safety, and Comparative Analysis
Introduction to Lisinopril 5mg
Lisinopril, an angiotensin-converting enzyme (ACE) inhibitor, is widely used to manage conditions such as hypertension, heart failure, and to improve survival after myocardial infarction. This article synthesizes research findings on the efficacy, safety, and comparative analysis of lisinopril at a 5mg dosage.
Efficacy in Heart Failure and Hypertension
Heart Failure Management
Research indicates that lisinopril at a 5mg dosage can significantly improve aerobic exercise capacity in heart failure patients. A study involving a randomized double-blind crossover trial with 12 symptomatic heart failure patients found that the 5mg dose resulted in higher aerobic exercise capacity compared to a 20mg dose (1696 vs 1578 ml.min(-1), P=0.016). Additionally, 73% of patients showed greater peak oxygen consumption and peak cardiac power output with the 5mg dose, suggesting that lower doses may optimize functional benefits in heart failure management.
Hypertension Control
In elderly patients with mild to moderate hypertension, lisinopril 5mg has been shown to be a safe and effective starting dose. An 8-week open-label study with 24 elderly patients demonstrated effective 24-hour blood pressure control, with most patients requiring a daily dose of 20-40mg for optimal results. The study concluded that lisinopril 5mg is a safe starting dose for elderly patients not on diuretics, effectively reducing blood pressure without significant side effects.
Comparative Efficacy with Other Treatments
Lisinopril vs. Enalapril
A comparative study of lisinopril (5-20mg) and enalapril (5-20mg) in 278 patients with mild-to-moderate heart failure showed that both ACE inhibitors significantly increased exercise duration after 6 and 12 weeks of treatment. Although there was a trend towards a greater increase in exercise duration with lisinopril, it did not reach statistical significance. Both drugs were equally effective in improving heart failure symptoms and were well tolerated.
Lisinopril vs. Digoxin
Another study compared lisinopril (5-20mg) with digoxin (0.125-0.375mg) in 217 patients with mild-to-moderate heart failure. After 12 weeks, lisinopril increased exercise duration more significantly than digoxin (51 seconds vs. 29 seconds, respectively). Both treatments had similar effects on heart failure symptoms and were equally well tolerated.
Safety and Side Effects
Adverse Reactions
The safety profile of lisinopril 5mg is generally favorable. In a study comparing 5mg and 20mg doses, fewer adverse reactions were reported during the 5mg phase (24 vs. 38 adverse reactions). Common side effects include cough, dizziness, and hypotension, but these are typically mild and manageable .
Renal Function Considerations
Lisinopril pharmacokinetics vary with renal function. In patients with severe renal failure, peak concentrations are higher, and the drug's half-life is extended, suggesting that smaller doses should be administered to these patients. This highlights the importance of dose adjustment based on renal function to avoid potential toxicity.
Quality and Equivalence of Lisinopril Brands
Physicochemical Equivalence
Studies evaluating the quality of different brands of lisinopril 5mg tablets in markets like Yemen and Sudan have shown that all tested brands meet the British Pharmacopoeia standards for weight uniformity, friability, disintegration, and dissolution . These findings confirm that generic lisinopril tablets are physically and chemically equivalent to branded versions, ensuring consistent efficacy and safety .
Conclusion
Lisinopril 5mg is an effective and safe starting dose for managing heart failure and hypertension, particularly in elderly patients. Comparative studies show that lisinopril is at least as effective as other ACE inhibitors and digoxin in improving exercise capacity and heart failure symptoms. The safety profile is favorable, with fewer adverse reactions at the 5mg dose. Additionally, generic lisinopril tablets are equivalent to branded versions, ensuring reliable treatment outcomes. Tailoring the dose based on individual patient needs, especially renal function, is crucial for optimizing therapeutic benefits.
Sources and full results
Most relevant research papers on this topic