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Lisinopril 20 mg Tablet: Visual Identification and Bioequivalence
Visual Identification of Lisinopril 20 mg Tablets
Lisinopril is a commonly prescribed medication for managing hypertension and heart failure. The 20 mg tablets of lisinopril are typically small, round, and may vary in color depending on the manufacturer. For instance, Zestril, a well-known brand, often comes in a pink, round tablet form, while other generic versions might differ slightly in appearance. It is crucial for patients to verify the appearance of their medication with a pharmacist to ensure they are taking the correct drug.
Bioequivalence of Lisinopril Tablets
Pharmacokinetic Profiles and Bioequivalence Studies
Several studies have been conducted to evaluate the bioequivalence of different brands of lisinopril tablets. One study compared the pharmacokinetic profiles of two brands of lisinopril 20 mg tablets, Lisotec and Zestril, in healthy volunteers. The study concluded that both brands exhibited comparable pharmacokinetic profiles, with no significant differences in parameters such as AUC (Area Under the Curve) and Cmax (maximum plasma concentration), indicating bioequivalence2.
Another study focused on the combination of lisinopril and hydrochlorothiazide, comparing the bioavailability of 20 mg lisinopril tablets and combined formulations of lisinopril/hydrochlorothiazide. The results showed that both the single and combined formulations were bioequivalent to their respective reference products, with 90% confidence intervals for pharmacokinetic parameters falling within the acceptable range4.
Impact of Food on Lisinopril Absorption
The absorption of lisinopril can be affected by food intake. Research has shown that there is a significant food effect on lisinopril, with a reduction of approximately 20%-25% in systemic exposure when the drug is taken postprandially (after a meal) compared to fasting conditions. This indicates that patients might experience different levels of drug efficacy depending on whether they take the medication with or without food1.
Tablet Splitting and Content Uniformity
For patients requiring dose adjustments, tablet splitting is a common practice. A study investigating the content uniformity of split lisinopril/hydrochlorothiazide tablets found that the halves of the tablets maintained consistent drug content, supporting the practice of tablet splitting for dose customization. This is particularly useful when a specific dosage form is not available, allowing for better individualization of therapy3.
Conclusion
Lisinopril 20 mg tablets, regardless of the brand, generally maintain bioequivalence, ensuring consistent therapeutic effects. However, patients should be aware of the impact of food on drug absorption and the viability of tablet splitting for dose adjustments. Always consult with a healthcare provider or pharmacist to confirm the correct appearance and usage of lisinopril tablets.
Sources and full results
Most relevant research papers on this topic
Pharmacokinetic and Bioequivalence Study of Lisinopril/Hydrochlorothiazide Tablet Under Fasting and Postprandial Conditions in Healthy Chinese Subjects
A single oral dose of generic lisinopril/hydrochlorothiazide is bioequivalent to the reference product and well-tolerated in healthy Chinese male and female participants, both under fasting and postprandial conditions.
RCTBioequivalence evaluation of two brands of lisinopril tablets (Lisotec and Zestril) in healthy human volunteers
Lisotec and Zestril are bioequivalent, with comparable pharmacokinetic profiles in healthy human volunteers.
RCTInfluence of tablet splitting on content uniformity of lisinopril/hydrochlorthiazide tablets.
Tablet splitting is an effective method for obtaining the prescribed dose of lisinopril/hydrochlorothiazide when a dosage form of the required strength is unavailable, and for better individualization of therapy.
Effect of the Combination of Lisinopril and Hydrochlorothiazide on the Bioequivalence of Tablet Formulations
Lisinopril and lisinopril/hydrochlorothiazide combined tablet formulations are bioequivalent to their reference formulations in terms of bioavailability.
RCTPharmacokinetics and bioequivalence of domestic and imported lisinopril tablets in healthy volunteers
Domestic and imported lisinopril tablets are bioequivalent in terms of pharmacokinetic parameters and bioavailability in healthy volunteers.
RCTEvaluation of Certain Pharmaceutical Quality Attributes of Lisinopril Split Tablets
Hand splitting of lisinopril tablets can lead to inaccurate doses and clinical safety issues, while using a tablet splitter can meet pharmacopoeia requirements for friability and disintegration time.
Lisinopril hydrochlorothiazide combination in treatment of patients with mild-to-moderate essential hypertension
Compound lisinopril is a safe and effective treatment for mild-to-moderate essential hypertension, with the most common adverse reaction being cough.
RCTEvaluation of some pharmaceutical formulations of lisinopril through dissolution testing.
Lisinopril 20 mg tablets (Antibiotice S.A. laşi) and Zestril 20 mg tablets (Astra Zeneca) both have similar dissolution profiles, with over 85% of the labeled amount dissolving in standard media at three pH values.
Characterization of an extemporaneous liquid formulation of lisinopril.
Lisinopril suspensions prepared from tablets are stable for at least four weeks when stored at or below 25 degrees C under ambient light exposure, with satisfactory chemical, physical, and microbiological results.
Lisinopril: dose-peak effect relationship in essential hypertension.
Lisinopril 10 and 20 mg doses have similar peak antihypertensive effects, but less than 80 mg doses, with no greater risk of first-dose symptomatic hypotension.
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