Lisinopril hctz 20 12.5 mg side effects
Pro Research Analysisby 
Searched over 200M research papers
Consensus Meter
Side Effects of Lisinopril-Hydrochlorothiazide 20/12.5 mg Combination
Common Side Effects
The combination of lisinopril 20 mg and hydrochlorothiazide 12.5 mg (L/HCTZ) is commonly used to treat hypertension. However, like all medications, it comes with potential side effects. One of the most frequently reported side effects is an increase in uric acid levels, which can lead to gout in susceptible individuals . Additionally, this combination can cause a decrease in potassium levels, which may necessitate monitoring and supplementation .
Metabolic Effects
L/HCTZ has been shown to have various metabolic effects. For instance, it can lead to a decrease in cholesterol levels, which is beneficial, but it can also cause an increase in fasting glucose levels, which may be a concern for diabetic patients. The combination also tends to increase triglycerides, although this effect is not significantly different from other treatments.
Cardiovascular Effects
The combination of lisinopril and hydrochlorothiazide has been found to be effective in reducing blood pressure, but it can also affect heart rate. Studies have shown that L/HCTZ can cause a slight reduction in heart rate, which is generally not significant but should be monitored in patients with pre-existing heart conditions .
Adverse Reactions
Adverse reactions to L/HCTZ are relatively common but are usually mild. These can include dizziness, headache, and fatigue. More serious but less common side effects include cough and angioedema, the latter being a potentially life-threatening condition that requires immediate medical attention . Cough is more frequently associated with lisinopril due to its ACE inhibitor component.
Comparison with Other Treatments
When compared to other antihypertensive treatments, L/HCTZ has a similar side effect profile. For example, it has been found to be as well-tolerated as captopril-hydrochlorothiazide combinations, with no significant differences in adverse events . However, L/HCTZ may offer advantages in terms of fewer incidences of cough and angioedema compared to other ACE inhibitors.
Conclusion
The combination of lisinopril 20 mg and hydrochlorothiazide 12.5 mg is effective in managing hypertension but comes with a range of potential side effects. These include metabolic changes like increased uric acid and decreased potassium levels, as well as cardiovascular effects such as a slight reduction in heart rate. While generally well-tolerated, it can cause adverse reactions like dizziness, headache, and more rarely, cough and angioedema. Monitoring and managing these side effects are crucial for the safe and effective use of this medication.
Sources and full results
Most relevant research papers on this topic