Lisinopril images
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Summary
10 papers analyzed
These studies suggest that lisinopril is effective in treating various cardiovascular conditions, can be used in combination with other drugs for enhanced benefits, and has potential applications in medical imaging and drug delivery systems.
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Lisinopril: Imaging and Clinical Applications
Lisinopril in Magnetic Resonance Imaging (MRI)
Regression of Left Ventricular Masses
Lisinopril has been shown to effectively reduce increased left ventricular (LV) masses in hypertensive patients. A study using magnetic resonance imaging (MRI) demonstrated that patients treated with lisinopril exhibited a significant decrease in LV mass and LV mass index compared to those who did not receive the drug. This suggests that lisinopril can be beneficial in managing hypertensive patients with increased LV masses.
Lisinopril-Loaded Superparamagnetic Nanoparticles
Innovative research has developed lisinopril-loaded superparamagnetic nanoparticles (MNPs-Lisinopril) as new T2 and T2* negative contrast agents for MRI. These nanoparticles not only serve as effective MRI contrast agents but also have potential applications in drug delivery and tumor diagnosis. The MNPs-Lisinopril demonstrated superior performance compared to commercial alternatives, with significant decreases in MR signal intensity correlating with increased nanoparticle concentration.
Lisinopril in Computed Tomography (CT) Imaging
Gold Nanoparticles for Cardiovascular Imaging
Lisinopril has been utilized to create gold nanoparticle-based CT contrast agents. These lisinopril-coated gold nanoparticles (GNPs) have shown high stability and effectiveness in targeting angiotensin-converting enzyme (ACE), which is overexpressed in conditions like cardiac and pulmonary fibrosis. CT images using these nanoparticles displayed high contrast in the lungs and heart, indicating successful targeting of ACE.
Technetium-Labeled Lisinopril Complexes
A series of technetium-labeled lisinopril complexes have been synthesized for in vivo imaging of ACE expression. These complexes demonstrated high specificity and affinity for ACE, with significant uptake in tissues expressing ACE, such as the lungs. This specificity was confirmed through biodistribution studies and planar anterior imaging analysis, making these complexes useful for monitoring ACE expression in diseases like heart failure.
Clinical Efficacy of Lisinopril
Post-Myocardial Infarction Management
Lisinopril has been extensively studied for its benefits in the early management of acute myocardial infarction (AMI). The GISSI-3 trial revealed that early administration of lisinopril significantly reduced mortality and severe left ventricular dysfunction in AMI patients. The trial also showed that lisinopril attenuated left ventricular dilatation, particularly in patients with larger infarcts . These findings underscore the importance of lisinopril in improving survival and cardiac function post-AMI.
Effects on Renal Function
In hypertensive and proteinuric renal transplant recipients, lisinopril effectively lowered systemic blood pressure without adversely affecting renal function. The study reported stable serum creatinine levels and glomerular filtration rates, along with a significant reduction in renal vascular resistance and proteinuria. This indicates that lisinopril can be safely used in renal transplant patients to manage hypertension and proteinuria.
Pulmonary Hypertension
Lisinopril has also been shown to attenuate acute hypoxic pulmonary vasoconstriction in humans. In a controlled study, lisinopril significantly blunted the increase in mean pulmonary artery pressure and total pulmonary vascular resistance induced by hypoxemia, without affecting systemic hemodynamics. This suggests a potential role for lisinopril in managing hypoxemic pulmonary hypertension.
Conclusion
Lisinopril is a versatile drug with significant applications in both imaging and clinical management. Its ability to reduce left ventricular mass, serve as a contrast agent in MRI and CT imaging, and improve outcomes in myocardial infarction and renal transplant patients highlights its multifaceted benefits. Additionally, its role in attenuating pulmonary hypertension further expands its therapeutic potential. These findings collectively support the continued use and exploration of lisinopril in various medical fields.
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