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These studies suggest that long-term lung symptoms can include substantial symptom burden in lung cancer survivors, multi-system symptoms and lung function concerns in post-acute COVID-19 patients, and diverse lung pathophysiology in long COVID-19 patients.
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Long lungs symptoms refer to the persistent respiratory and systemic symptoms experienced by individuals long after the initial recovery from lung-related diseases or infections. These symptoms can significantly impact the quality of life and require ongoing medical attention. This article synthesizes research findings on long-term symptoms associated with lung cancer and post-acute COVID-19 syndrome, commonly known as long COVID.
Long-term lung cancer survivors (LTLCS) often experience a significant symptom burden that affects their quality of life (QOL). A longitudinal study involving 447 LTLCS identified that 35% of survivors reported a decline in overall QOL over time, with common symptoms including fatigue (69%), pain (59%), dyspnea (58%), depressed appetite (49%), and coughing (42%). These symptoms persisted despite some survivors reporting an improvement in overall QOL, indicating an adaptation to their compromised physical condition.
Effective management of symptoms in lung cancer patients is crucial. Recommendations for managing common symptoms such as pain, dyspnea, cough, and fatigue have been developed to improve patient compliance and QOL. These guidelines emphasize the importance of recognizing and addressing cancer-related symptoms to enhance patient outcomes.
Post-acute COVID-19 syndrome, or long COVID, is characterized by the persistence of symptoms for months after the initial infection. Studies have shown that a significant proportion of COVID-19 survivors experience long-term symptoms, with fatigue (47%) and psychosocial issues (28%) being the most prevalent. Additionally, abnormalities in lung function, such as reduced diffusing capacity for carbon monoxide (DLCO), are common among recovering patients .
Long COVID can lead to persistent respiratory symptoms, including breathlessness and reduced lung volumes. Despite these impairments, patients with long COVID and dyspnea exhibit similar physiological responses to exercise as healthy individuals, suggesting that DLCO impairment alone cannot fully explain the complexity of long COVID symptoms.
Children with a history of COVID-19 infection can also develop long COVID, presenting symptoms such as fatigue, cough, exercise intolerance, and dyspnea. However, studies have found no significant differences in lung function and structural abnormalities between children with long COVID and asymptomatic peers. This indicates the need for further research to understand the underlying mechanisms and potential markers, such as fractional exhaled nitric oxide (FeNO), in pediatric long COVID cases.
Long lungs symptoms, whether resulting from lung cancer or post-acute COVID-19, pose significant challenges to survivors. Persistent symptoms such as fatigue, dyspnea, and cough can severely impact the quality of life, necessitating targeted interventions and ongoing medical care. Understanding the prevalence, types, and management of these symptoms is crucial for improving patient outcomes and guiding future research.
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