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These studies suggest that weight loss in women with PCOS can improve metabolic, endocrine, reproductive, cardiovascular, and psychological features, and can be effectively achieved through lifestyle interventions, cognitive-behavioral therapy, and pharmacologic therapy.
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Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder among women of reproductive age, often accompanied by obesity and metabolic complications. Effective weight management is crucial for improving the reproductive, metabolic, and psychological symptoms associated with PCOS .
Weight loss has been shown to significantly improve health-related quality of life (HRQOL) and reduce depressive and anxiety symptoms in women with PCOS. A study found that both weight loss and the use of oral contraceptive pills (OCP) led to improvements in various physical and mental health domains, with combined therapies offering further benefits.
Losing 5-10% of body weight can lead to significant improvements in metabolic and reproductive health. This includes better insulin sensitivity, reduced androgen levels, and improved ovulation rates . Both high-protein and high-carbohydrate hypocaloric diets have been effective in achieving weight loss and improving metabolic and reproductive abnormalities in women with PCOS.
Lifestyle interventions, including diet and exercise, are the cornerstone of weight management in PCOS. These interventions have shown moderate short-term effects on weight loss and improvements in metabolic and reproductive health. A systematic review highlighted that lifestyle modifications, such as a healthy diet and increased physical activity, are essential for sustainable weight loss.
Incorporating cognitive behavioral therapy (CBT) into weight management programs can enhance the effectiveness of lifestyle interventions. A study protocol for a randomized controlled trial (RCT) suggested that a three-component intervention involving CBT, diet, and physical activity could lead to long-term weight loss and improved PCOS symptoms. Another RCT confirmed that CBT combined with lifestyle interventions was effective in achieving significant weight loss.
Pharmacologic therapies, such as metformin and exenatide, have been used to induce weight loss in women with PCOS. However, lifestyle interventions, particularly those that are internet-based and intensive, have shown superior results in reducing weight and improving insulin resistance compared to pharmacologic treatments alone.
Despite the benefits of weight loss, achieving and maintaining it can be challenging. High dropout rates in weight management programs indicate the need for more supportive and sustainable approaches. Personalized interventions that consider individual psychological and behavioral factors may enhance adherence and outcomes .
Weight loss is a critical component in managing PCOS, offering significant improvements in metabolic, reproductive, and psychological health. Combining lifestyle interventions with cognitive behavioral therapy and, when necessary, pharmacologic treatments, can provide a comprehensive approach to weight management in women with PCOS. Further research is needed to optimize these strategies and ensure long-term success.
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