Lowest dose of lisinopril
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Lowest Dose of Lisinopril: Insights from Research Studies
Introduction to Lisinopril Dosage
Lisinopril, an angiotensin-converting enzyme (ACE) inhibitor, is widely used for treating hypertension, heart failure, and other cardiovascular conditions. Understanding the lowest effective dose is crucial for optimizing therapeutic outcomes while minimizing side effects.
Pediatric Hypertension: Effective Low Dose
A study on hypertensive children aged 6 to 16 years explored the dose-response relationship of lisinopril. The research found that an initial dose of 0.07 mg/kg administered once daily effectively lowered blood pressure within two weeks. This dose was well-tolerated and showed a consistent dose-response relationship across various subgroups, including age, gender, and ethnicity.
Safety in Pediatric Ingestions
A retrospective study analyzed lisinopril ingestions in children under six years old. The study concluded that pediatric ingestions of lisinopril up to 4 mg/kg or 40 mg total could be safely managed at home, as no significant hypotension or severe adverse effects were observed at these doses.
Low-Dose Efficacy in Adults
In adults with mild to moderate hypertension, a multicenter study compared the antihypertensive effects of various doses of lisinopril. The study demonstrated that even low doses, such as 10 mg/day, were effective in reducing blood pressure. The combination of lisinopril with hydrochlorothiazide at low doses also showed significant antihypertensive effects without serious side effects.
Pharmacokinetics in Pediatric Patients
A pharmacokinetic study in children aged 6 months to 15 years administered lisinopril at a dose of 0.15 mg/kg per day. The study reported that this dose was well-tolerated and effective in managing hypertension, with no serious adverse events related to lisinopril.
Migraine Prophylaxis with Low Dose
An open-label study investigated the use of a low dose of lisinopril (5 mg daily) for migraine prevention. The study found that this low dose significantly reduced the frequency of migraine attacks and the need for acute migraine medications, although some patients experienced intolerable cough.
Heart Failure: Low vs. High Dose
A large-scale study compared low (2.5 to 5.0 mg daily) and high (32.5 to 35 mg daily) doses of lisinopril in patients with chronic heart failure. The findings suggested that while higher doses reduced hospitalizations more effectively, low doses were still beneficial and well-tolerated, indicating that very low doses should be used only if higher doses are not tolerated.
Conclusion
Research indicates that low doses of lisinopril are effective and well-tolerated in both pediatric and adult populations for various conditions, including hypertension and migraine prophylaxis. In pediatric patients, doses as low as 0.07 mg/kg can effectively manage hypertension, while in adults, doses starting from 10 mg/day are sufficient for significant blood pressure reduction. These findings highlight the importance of individualized dosing to achieve optimal therapeutic outcomes with minimal side effects.
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