Malaria control efforts using bednets and artemisinin-based therapies have reduced the global burden, but increased resources and regional cooperation are needed for further substantial inroads into the disease burden.

Malaria

Malaria control efforts have reduced the disease prevalence by over half, with new tools like vaccines and drugs playing a crucial role in eradication.

Malaria: Biology and Disease

Malaria immunity in humans and mosquitoes is complex and evolving, with potential for eradication through vaccines and vector control strategies.

Malaria immunity in man and mosquito: insights into unsolved mysteries of a deadly infectious disease.

Malaria is a preventable and treatable infectious disease that kills more than half a million people annually, disproportionately impacting women, young children, and the most poor and vulnerable.

Malaria is a global public health burden with 229 million cases reported in 2019, and effective management requires combination therapy and personal protective measures to prevent drug resistance.

Malaria: An Overview

Plasmodium species cause human malaria, with five main species (P. falciparum, P. vivax, P. malariae, P. ovale, and P. knowlesi) and their ability to adapt to environmental changes and host specificity makes them a significant threat to human health.

Plasmodium—a brief introduction to the parasites causing human malaria and their basic biology

Malaria resurgence is primarily due to drug-resistant strains, insecticide-resistant mosquitoes, and lack of licensed vaccines, with a complex life cycle and complex parasite life cycle.

Malaria − an overview

Malaria has been fought globally for over 60 years, with early diagnosis, timely treatment, and prevention being key to reducing the disease burden, but recent trends show a slowdown in progress towards WHO targets.

Malaria: The Past and the Present

Malaria pathogenesis involves the interaction of parasite biology and human pathophysiological response, with variations in parasite genetics, co-infections, and environmental factors.

Malaria Pathogenesis.

The number of malaria cases in the United States decreased by 208 from 2014 to 2015, with West Africa being the only region with significantly fewer imported cases.

Malaria Surveillance — United States, 2015

Malaria research should focus on understanding its pathogenesis and developing affordable, effective tools like vaccines to reduce disease and improve access to treatment in underdeveloped countries.

The pathogenic basis of malaria

Our novel convolutional neural network architecture accurately detects malaria from blood samples with 99.68% accuracy, making it a promising tool for resource-limited settings.

Malaria Detection Using Advanced Deep Learning Architecture

Malaria is a life-threatening parasitic infection caused by Plasmodium spp., transmitted by Anopheles spp. mosquitoes, and proper treatment requires knowledge of the infecting species and where it was acquired.

Malaria prevention through vector control, bed nets, prompt diagnosis, and effective anti-malarial drugs significantly reduces anaemia burden in tropical countries.

Anaemia and malaria

Malaria diagnosis and prompt treatment are crucial for preventing complications and saving lives in endemic areas, especially in children.

Malaria in Children.

Malaria in Brazil is a major public health issue, with a focus on reducing morbidity and mortality through integrated control efforts.

Malaria in Brazil: an overview

Understanding the basic mechanisms of malaria infection and tissue pathology may lead to new diagnostics and treatments, including new treatments for cerebral malaria.

Malaria: mechanisms of erythrocytic infection and pathological correlates of severe disease.

Innate immune mechanisms against Plasmodium parasites may contribute to rapid protection against malaria and modulate adaptive immune responses, offering a potential new approach to malaria vaccine development.

Innate immunity to malaria

Malaria parasites use genetic changes, biomolecular exposure, and intracellular replication to evade the immune system, increasing their survival in both mosquitoes and vertebrate hosts.

Immune Escape Strategies of Malaria Parasites

Malaria can cause acute kidney injury (AKI), with potential mechanisms including acute tubular necrosis, infection-triggered proinflammatory reactions, and metabolic disturbances.

Malaria and acute kidney injury

These studies suggest that malaria control efforts, including bednets, artemisinin-based therapies, vaccines, and vector control, have significantly reduced the global burden, but challenges like drug resistance, insecticide resistance, and the need for increased resources and regional cooperation remain.