Is Mangosteen Juice safe?
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Safety of Mangosteen Juice: An Overview
Introduction to Mangosteen Juice Safety
Mangosteen juice, derived from the tropical fruit Garcinia mangostana, is widely consumed for its purported health benefits. However, questions about its safety remain. This article synthesizes findings from multiple studies to provide a comprehensive overview of the safety of mangosteen juice.
Inflammation and Antioxidant Effects
Anti-Inflammatory Properties
A pilot study evaluated the effects of a proprietary mangosteen juice blend on inflammation markers in obese individuals. The study found that high doses of the juice (18 oz per day) significantly reduced C-reactive protein (CRP) levels, a marker of inflammation, compared to a placebo. Importantly, no side effects were reported, and safety assessments showed no clinically significant changes in laboratory or EKG results.
Antioxidant Activity
Research has shown that xanthones, the active polyphenols in mangosteen juice, are absorbed and partially conjugated in the human body. These compounds are known for their antioxidant properties, which may contribute to the juice's health benefits. Additionally, a study on a probiotic beverage made from mangosteen juice demonstrated good antioxidant activity, suggesting potential health benefits.
Safety Concerns and Adverse Effects
Misleading Marketing and Methodological Weaknesses
A critical review highlighted that many marketing claims about mangosteen juice are based on low-quality research. These claims often overstate the benefits and fail to disclose methodological weaknesses, potentially misleading consumers about the product's safety and efficacy.
Severe Adverse Reactions
There have been reports of severe adverse reactions associated with mangosteen juice. One case study described a severe lactic acidosis incident linked to the consumption of mangosteen juice, raising concerns about its safety as a dietary supplement. This underscores the need for caution and further research to fully understand the potential risks.
General Safety and Toxicity
A broader review of botanical dietary supplements, including mangosteen, indicated that while these products are generally considered safe, there are conflicting results from safety studies. This suggests that more rigorous research is needed to confirm the safety of mangosteen juice.
Conclusion
While mangosteen juice has shown potential anti-inflammatory and antioxidant benefits, its safety profile is not fully established. Some studies report no adverse effects, while others highlight severe reactions and methodological flaws in existing research. Consumers should exercise caution and consult healthcare professionals before incorporating mangosteen juice into their diet. Further large-scale, high-quality studies are essential to conclusively determine the safety and efficacy of mangosteen juice.
Sources and full results
Most relevant research papers on this topic
Evaluation of Mangosteen juice blend on biomarkers of inflammation in obese subjects: a pilot, dose finding study
Science in liquid dietary supplement promotion: the misleading case of mangosteen juice.
Xanthones in mangosteen juice are absorbed and partially conjugated by healthy adults.
Acute Garcinia mangostana (mangosteen) supplementation does not alleviate physical fatigue during exercise: a randomized, double-blind, placebo-controlled, crossover trial
Usage, biological activity, and safety of selected botanical dietary supplements consumed in the United States
Severe lactic acidosis associated with juice of the mangosteen fruit Garcinia mangostana.
Shelf life of non-industrial fresh mango juice: Microbial safety, nutritional and sensory characteristics
Probiotic Beverage from Mangosteen Juice Fermented with Lactobacillus Strains
The effect of heating temperature on cytotoxicity and α-mangostin yield: Mangosteen pericarp juice and mangosteen extract
Quality of mangosteen juice colored with mangosteen pericarp.
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