Is Mangosteen Juice safe?
Pro Research Analysisby 
Searched over 200M research papers
Safety of Mangosteen Juice: An Overview
Introduction to Mangosteen Juice Safety
Mangosteen juice, derived from the tropical fruit Garcinia mangostana, is widely consumed for its purported health benefits. However, questions about its safety remain. This article synthesizes findings from multiple studies to provide a comprehensive overview of the safety of mangosteen juice.
Inflammation and Antioxidant Effects
Anti-Inflammatory Properties
A pilot study evaluated the effects of a proprietary mangosteen juice blend on inflammation markers in obese individuals. The study found that high doses of the juice (18 oz per day) significantly reduced C-reactive protein (CRP) levels, a marker of inflammation, compared to a placebo. Importantly, no side effects were reported, and safety assessments showed no clinically significant changes in laboratory or EKG results1.
Antioxidant Activity
Research has shown that xanthones, the active polyphenols in mangosteen juice, are absorbed and partially conjugated in the human body. These compounds are known for their antioxidant properties, which may contribute to the juice's health benefits3. Additionally, a study on a probiotic beverage made from mangosteen juice demonstrated good antioxidant activity, suggesting potential health benefits8.
Safety Concerns and Adverse Effects
Misleading Marketing and Methodological Weaknesses
A critical review highlighted that many marketing claims about mangosteen juice are based on low-quality research. These claims often overstate the benefits and fail to disclose methodological weaknesses, potentially misleading consumers about the product's safety and efficacy2.
Severe Adverse Reactions
There have been reports of severe adverse reactions associated with mangosteen juice. One case study described a severe lactic acidosis incident linked to the consumption of mangosteen juice, raising concerns about its safety as a dietary supplement6. This underscores the need for caution and further research to fully understand the potential risks.
General Safety and Toxicity
A broader review of botanical dietary supplements, including mangosteen, indicated that while these products are generally considered safe, there are conflicting results from safety studies. This suggests that more rigorous research is needed to confirm the safety of mangosteen juice5.
Conclusion
While mangosteen juice has shown potential anti-inflammatory and antioxidant benefits, its safety profile is not fully established. Some studies report no adverse effects, while others highlight severe reactions and methodological flaws in existing research. Consumers should exercise caution and consult healthcare professionals before incorporating mangosteen juice into their diet. Further large-scale, high-quality studies are essential to conclusively determine the safety and efficacy of mangosteen juice.
Sources and full results
Most relevant research papers on this topic
Evaluation of Mangosteen juice blend on biomarkers of inflammation in obese subjects: a pilot, dose finding study
A proprietary mangosteen juice blend (XanGo JuiceTM) reduced CRP levels in obese individuals compared to placebo, but other inflammation markers and lipid peroxidation markers showed no significant differences.
RCT
Very Rigorous Journal
Highly CitedScience in liquid dietary supplement promotion: the misleading case of mangosteen juice.
Mangosteen juice marketing claims often overstate the significance of findings and fail to disclose methodological weaknesses in cited research, potentially misleading consumers about product safety and effectiveness.
Xanthones in mangosteen juice are absorbed and partially conjugated by healthy adults.
Mangosteen juice's xanthones are absorbed and partially conjugated in healthy adults when ingested with a high-fat meal, but their release from pericarp particles during digestion may be limited.
Non-RCTVery Rigorous JournalHighly CitedAcute Garcinia mangostana (mangosteen) supplementation does not alleviate physical fatigue during exercise: a randomized, double-blind, placebo-controlled, crossover trial
Acute mangosteen supplementation does not alleviate physical fatigue during exercise, except for a positive impact on mood states.
RCTVery Rigorous JournalUsage, biological activity, and safety of selected botanical dietary supplements consumed in the United States
Aça, noni, mangosteen, black chokeberry, and maqui berry show potential in dietary supplements due to their antioxidant, anti-inflammatory, and neuroprotective properties.
Literature Review
Rigorous JournalSevere lactic acidosis associated with juice of the mangosteen fruit Garcinia mangostana.
Mangosteen fruit juice, marketed as a dietary supplement, can cause severe lactic acidosis in some individuals.
Case ReportShelf life of non-industrial fresh mango juice: Microbial safety, nutritional and sensory characteristics
Non-industrial fresh mango juice can be safely consumed within 8 hours at 4, 25 and 37°C, with good quality maintained within 2 hours at 4 or 25°C.
Probiotic Beverage from Mangosteen Juice Fermented with Lactobacillus Strains
Mangosteen juice fermented with Lactobacillus strains has high acceptability and taste, but may have higher toxicity to colon tumor cells than unfermented mangosteen juice.
The effect of heating temperature on cytotoxicity and α-mangostin yield: Mangosteen pericarp juice and mangosteen extract
Heating mangosteen pericarp juice at 65°C for 30 minutes prior to blending increases -mangostin yield and cytotoxicity, resulting in higher antitumor and antiviral properties.
Quality of mangosteen juice colored with mangosteen pericarp.
Mangosteen juice colored with mangosteen pericarp maintains its quality and shelf life for at least 5 weeks at 4°C, with stable total soluble solids and acceptable bacteria, yeast, and mold counts.
Try another search
How do bees decide when to swarm?
How do we understand and model the effects of bilingualism on cognitive function?
What are the signs of hidden food allergies or sensitivities?
what is the meaning of covariant derivatives?
What is the recommended daily intake of fiber?
What are the strategies for mitigating the environmental impacts of electronic waste through recycling and sustainable design?