May cancer
Searched over 200M research papers for "may cancer"
Summary
10 papers analyzed
These studies suggest that cancer diagnosis and progression are influenced by specific biomarkers, physical traits, genetic factors, dietary habits, microbial interactions, socioeconomic status, and early detection strategies.
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Diagnostic Features of Basal Cell Carcinoma: The Role of MAY Globules
Introduction to Basal Cell Carcinoma (BCC)
Basal cell carcinoma (BCC) is the most common type of skin cancer, often diagnosed through dermoscopic imaging. However, identifying nonpigmented BCCs remains challenging due to limited diagnostic features such as arborizing vessels, ulceration, and shiny white structures.
Multiple Aggregated Yellow-White (MAY) Globules as a Diagnostic Criterion
Recent research has identified multiple aggregated yellow-white (MAY) globules as a potential new diagnostic feature for BCC. In a study involving 656 nonpigmented lesions, MAY globules were observed in 21% of BCC cases but only 0.8% of other diagnoses, indicating a high specificity for BCC diagnosis. The presence of MAY globules was also associated with histologic high-risk BCC subtypes, suggesting their utility in identifying more aggressive forms of the disease.
The Role of APRIL in Cancer and Autoimmunity
APRIL and Its Receptors
APRIL (a proliferation-inducing ligand) is a member of the TNF cytokine family, recently linked to both autoimmunity and cancer. Studies have identified specific receptors for APRIL, highlighting its role in the survival and proliferation of cancer cells. Elevated levels of APRIL have been correlated with advanced disease stages and malignant phenotypes, making it a potential biomarker and therapeutic target in various cancers.
Genetic and Physical Traits of Cancer
Chromosome Aberrations
Cancer is characterized by a series of genetic events involving oncogenes and tumor suppressor genes. Consistent chromosome aberrations have been linked to specific cancer types, aiding in the identification of mutated genes and understanding their mechanisms. These genetic alterations are crucial for the development and progression of cancers such as lung, colon, and breast cancer.
Physical Traits of Tumors
The physical properties of tumors, including solid stress, interstitial fluid pressure, stiffness, and altered microarchitecture, significantly impact cancer progression and treatment resistance. These traits disrupt normal tissue structure and function, promoting tumor growth and immune evasion. Understanding these physical abnormalities provides new avenues for therapeutic strategies and drug discovery.
Socioeconomic Factors and Cancer
Cancer in Socioeconomically Disadvantaged Populations
Cancer affects individuals across all socioeconomic levels, but the burden is increasingly shifting towards developing countries. Socioeconomic disparities influence cancer incidence, access to treatment, and survival rates. Efforts to address these disparities are crucial for improving global cancer outcomes.
Conclusion
The identification of MAY globules as a diagnostic feature for BCC, the role of APRIL in cancer progression, and the understanding of genetic and physical traits of tumors are significant advancements in cancer research. Addressing socioeconomic disparities and leveraging these insights can enhance cancer diagnosis, treatment, and prevention strategies.
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