High cholesterol levels in the blood increase the risk of developing heart disease.

Hypercholesterolemia

Familial hypercholesterolemia is a genetic condition, and if inherited, it increases a person's risk of developing heart disease.

Familial Hypercholesterolemia: The Most Common Monogenic Disorder in Humans.

Familial hypercholesterolemia is an inherited condition characterized by high cholesterol levels in the blood, increasing a person's risk of developing heart disease.

Familial Hypercholesterolemia: A Reportable Disorder.

Familial hypercholesterolaemia is a common inherited disorder with elevated LDL cholesterol levels, which can lead to cardiovascular disease, and lifelong LDL cholesterol-lowering treatment significantly improves CVD-free survival and longevity.

Familial hypercholesterolaemia

High cholesterol levels are a significant risk factor for coronary heart disease, and public education campaigns and media exposure have led to a decline in average levels.

Cholesterol issues as viewed from the United States

Elevated cholesterol levels (hyperlipidemia) or imbalanced lipid levels (dyslipidemia) can increase the risk of heart and blood vessel diseases, such as heart attack, stroke, or peripheral artery disease.

Vascular Disease Patient Information Page: Understanding cholesterol

High levels of cholesterol are generally considered to be associated with atherosclerosis. In the past two decades, however, a number of studies have shown that excess cholesterol accumulation in various tissues and organs plays a critical role in the pathogenesis of multiple diseases. Here, we summarize the effects of excess cholesterol on disease pathogenesis, including liver diseases, diabetes, chronic kidney disease, Alzheimer's disease, osteoporosis, osteoarthritis, pituitary-thyroid axis dysfunction, immune disorders, and COVID-19, while proposing that excess cholesterol-induced toxicity is ubiquitous. We believe this concept will help broaden the appreciation of the toxic effect of excess cholesterol, and thus potentially expand the therapeutic use of cholesterol-lowering medications.

Cholesterol-induced toxicity: An integrated view of the role of cholesterol in multiple diseases.

Elevated serum uric acid increases the risk for developing high LDL cholesterol and hypertriglyceridemia, potentially shedding light on its role in cardiovascular disease.

Elevated serum uric acid increases risks for developing high LDL cholesterol and hypertriglyceridemia: A five-year cohort study in Japan.

From 1980 to 2018, total and non-HDL cholesterol levels increased in low- and middle-income countries, particularly in east and southeast Asia, and decreased in high-income western countries.

Repositioning of the global epicentre of non-optimal cholesterol

Inherited disorders of cholesterol biosynthesis can lead to low cholesterol levels, which may have severe consequences for human health and development.

Inherited disorders of cholesterol biosynthesis

Extremely high levels of HDL-C are associated with an increased risk of atherosclerotic cardiovascular disease mortality, particularly in current drinkers.

Association of extremely high levels of high-density lipoprotein cholesterol with cardiovascular mortality in a pooled analysis of 9 cohort studies including 43,407 individuals: The EPOCH-JAPAN study.

High HDL levels, regardless of CETP deficiency, are protective against coronary heart disease, regardless of the presence of CETP mutations.

A low prevalence of coronary heart disease among subjects with increased high-density lipoprotein cholesterol levels, including those with plasma cholesteryl ester transfer protein deficiency.

PCSK9 inhibition shows promise as a well-tolerated treatment option for familial hypercholesterolaemia, reducing LDL-C levels significantly in patients receiving maximally tolerated statin treatment.

Management of patients with familial hypercholesterolaemia

Increased HDL-C levels are a significant predictor of reduced cardiovascular disease risk, with treatment with gemfibrozil reducing death or MI by 22% and lowering total cholesterol by 4%.

High-density lipoprotein cholesterol as an independent risk factor in cardiovascular disease: assessing the data from Framingham to the Veterans Affairs High--Density Lipoprotein Intervention Trial.

HDL cholesterol levels in plasma do not necessarily reflect the efficacy and antiatherogenicity of reverse cholesterol transport, with HDL subclass concentration, lipid mobilization, and metabolism being key determinants.

High density lipoproteins and arteriosclerosis. Role of cholesterol efflux and reverse cholesterol transport.

Hypercholesterolaemia promotes inflammation, which worsens chronic metabolic diseases like atherosclerosis and obesity, but therapeutic interventions like increased HDL production may help.

Cholesterol, inflammation and innate immunity

Low HDL cholesterol levels are an independent predictor of coronary artery disease and predict total mortality, with niacin being the most effective medication for raising HDL cholesterol levels.

The antiatherogenic role of high-density lipoprotein cholesterol.

Extreme high HDL cholesterol levels are paradoxically associated with high all-cause mortality in both men and women.

Extreme high high-density lipoprotein cholesterol is paradoxically associated with high mortality in men and women: two prospective cohort studies

Higher cholesterol efflux capacity from macrophages is strongly associated with reduced carotid intima-media thickness and reduced likelihood of coronary artery disease, independent of HDL cholesterol levels.

Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis.

Elevated non-HDL-C levels at all life stages are associated with coronary atherosclerosis in mid-adulthood, with a stronger association observed in adolescence.

Association of Non-High-Density Lipoprotein Cholesterol Measured in Adolescence, Young Adulthood, and Mid-Adulthood With Coronary Artery Calcification Measured in Mid-Adulthood.

These studies suggest the medical name for high cholesterol is hypercholesterolemia.

Medical name for high cholesterol

Summary

Not a yes or no question