Metformin and eggs
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Summary
10 papers analyzed
These studies suggest metformin can improve egg production and ovarian function in hens, while other studies indicate it can disrupt development and reproductive processes in fish.
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Metformin and Its Effects on Egg Production and Aquatic Life
Metformin and Egg Production in Hens
Metformin's Impact on Laying Hens
Metformin, a common anti-diabetic drug, has been shown to influence egg production and liver health in laying hens. Research indicates that metformin can significantly reduce lipid deposits in the liver, which is beneficial for hens suffering from non-alcoholic fatty liver disease. In a study involving Leghorn laying hens, metformin administration led to decreased plasma triglyceride, cholesterol, and insulin levels, as well as reduced body and abdominal fat weights. Additionally, there was an increase in hepatic enzymes related to lipid metabolism, suggesting that metformin effectively improves liver health and reduces fat accumulation.
Enhanced Reproductive Efficiency in Broiler Breeder Hens
Further studies have demonstrated that metformin can improve ovarian function and increase egg production in broiler breeder hens. These hens, which often suffer from reproductive inefficiencies similar to polycystic ovary syndrome (PCOS) in women, showed significant improvements in egg production, fertility, and hatchability when treated with metformin. The drug normalized ovarian follicular hierarchy and altered plasma reproductive hormone profiles, leading to better reproductive outcomes.
Metformin's Environmental Impact on Aquatic Life
Effects on Fathead Minnows
Metformin's presence in aquatic environments, primarily through municipal wastewater, has raised concerns about its impact on fish. Studies on fathead minnows (Pimephales promelas) have shown mixed results. Chronic exposure to metformin at environmentally relevant concentrations did not significantly affect the survival, growth, or gut microbiome of larval fish. However, other research indicated that juvenile minnows exhibited increased expression of genes related to estrogenic effects, suggesting age-dependent susceptibility to metformin.
Zebrafish Development and Reproduction
In zebrafish (Danio rerio), metformin exposure has been linked to significant developmental and reproductive disruptions. Chronic exposure to metformin resulted in increased expression of vitellogenin, a protein associated with estrogenic activity, in male zebrafish. This led to reduced fecundity and increased incidence of intersex conditions. Additionally, metformin exposure caused oxidative stress and morphological abnormalities in zebrafish embryos, further highlighting its potential environmental risks .
Conclusion
Metformin has demonstrated beneficial effects on egg production and liver health in hens, making it a valuable tool for improving poultry reproductive efficiency. However, its environmental impact, particularly on aquatic life, raises significant concerns. The drug's presence in water bodies can disrupt fish development and reproduction, indicating a need for careful management of pharmaceutical waste to mitigate these adverse effects.
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