Metoprolol and drinking alcohol
Searched over 200M research papers
Summary
3 papers analyzed
These studies suggest that alcohol does not negate the antihypertensive effect of metoprolol and that metoprolol may help prevent alcohol-induced cardiac hypertrophy.
Not a yes or no question
To use the Consensus Meter, try asking a simple yes or no question
Research summarized with Copilot
Beta19 papers analyzed
Interaction Between Metoprolol and Alcohol Consumption
Metoprolol and Alcohol: Blood Pressure Effects
The interaction between metoprolol, a beta-blocker, and alcohol has been studied to understand its impact on blood pressure control. A study involving eight healthy men examined the acute effects of consuming alcohol after a single oral dose of 200 mg of metoprolol. The results indicated that alcohol, in a dose of 0.75 g/kg body weight, did not negate the antihypertensive effect of metoprolol on supine systolic blood pressure. However, the study highlighted the need for further investigation into the interaction of alcohol with antihypertensive drugs, especially since hypertensive patients who consume alcohol regularly tend to have less adequate blood pressure control.
Metoprolol and Ethanol-Induced Cardiac Hypertrophy
Research on rats has shown that severe intoxication with ethanol stimulates the peripheral sympathetic nervous system, leading to increased excretion of adrenaline and noradrenaline, and rapid development of cardiac hypertrophy. Metoprolol, when administered at a high dose (100 mg/kg, t.i.d.), was found to reduce adrenal catecholamine content and diminish cardiac weight in control animals. When combined with ethanol, metoprolol enhanced the loss of medullary catecholamine and reduced cardiac noradrenaline content, although the cardiac weight remained the same as in control animals. This suggests a beta-adrenoceptor mediated link in the cardiac hypertrophy induced by ethanol, which metoprolol can antagonize.
Cardioprotective Effects of Beta-Blockers Against Alcohol-Induced Damage
Heavy alcohol consumption is associated with poor cardiac contractility, mitochondrial dysfunction, and ventricular arrhythmias. In studies involving rats, acute alcohol administration significantly raised plasma cardiac troponin-T levels, a marker for myocardial damage. While beta-blocker pretreatment with propranolol reduced the alcohol-induced increase in plasma troponin-T, metoprolol and atenolol were unable to achieve the same effect. This indicates that not all beta-blockers have the same cardioprotective effects against alcohol-induced heart muscle damage.
Conclusion
The interaction between metoprolol and alcohol presents a complex picture. While metoprolol does not negate its antihypertensive effects when alcohol is consumed, it plays a role in mitigating ethanol-induced cardiac hypertrophy through beta-adrenoceptor mediation. However, its effectiveness in reducing alcohol-induced myocardial damage, as indicated by plasma cardiac troponin-T levels, is limited compared to other beta-blockers like propranolol. Further research is necessary to fully understand the implications of alcohol consumption in patients undergoing treatment with metoprolol.
Sources and full results
Most relevant research papers on this topic
