Metoprolol side effects weight loss
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Metoprolol Side Effects: Weight Loss
Introduction to Metoprolol and Weight Loss
Metoprolol, a beta-blocker commonly used to treat hypertension and other cardiovascular conditions, has been studied for its potential side effects, including its impact on weight. This article synthesizes findings from multiple research studies to provide a comprehensive overview of how metoprolol affects weight loss.
Metoprolol and Weight Management in Obese Patients
Combination Therapy with Sibutramine
A study investigated the effects of combining low-dose metoprolol with sibutramine, an appetite suppressant, in obese patients. The results showed that while both groups (sibutramine plus placebo and sibutramine plus metoprolol) experienced significant weight loss, the addition of metoprolol did not negatively impact the weight loss achieved. Moreover, the combination therapy improved patient compliance and reduced side effects such as palpitations and hypertension without causing significant metabolic changes.
Weight Reduction in Hypertensive Patients
In a randomized controlled trial comparing weight reduction and metoprolol treatment in young, overweight hypertensive patients, it was found that weight reduction alone led to significant decreases in both systolic and diastolic blood pressure. The metoprolol group also saw reductions in blood pressure, but these were accompanied by adverse effects on plasma lipids, such as a decrease in HDL-cholesterol and an increase in the total to HDL-cholesterol ratio .
Impact on Left Ventricular Mass
Another study focused on the effects of weight reduction and metoprolol on left ventricular mass in hypertensive patients. The weight reduction group experienced significant decreases in left ventricular mass and wall thickness, which were greater than those observed in the metoprolol and placebo groups. This suggests that weight loss, independent of blood pressure changes, can significantly reduce cardiac hypertrophy.
Conclusion
The research indicates that while metoprolol does not directly contribute to weight loss, it does not hinder weight loss efforts when used in combination with other treatments like sibutramine. However, weight reduction alone appears to offer more significant cardiovascular benefits without the adverse lipid profile changes associated with metoprolol. Therefore, for overweight hypertensive patients, focusing on weight reduction may provide more comprehensive health benefits.
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