How much Black Cohosh Root should I take daily?
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Summary
2 papers analyzed
These studies suggest that black cohosh root is well-tolerated and safe at certain doses, but do not provide specific guidance on the exact daily amount that should be taken by humans.
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Research on the use of Black Cohosh root, particularly in the form of dietary supplements, has focused on its application for menopausal symptoms and its pharmacokinetics, as well as its potential immunomodulatory effects.
Key Insights:
- The maximum tolerated dose of a 75% ethanol extract of Black Cohosh was investigated, and no acute toxicity was observed at single doses containing up to 5.6 mg of the compound 23-epi-26-deoxyactein. Pharmacokinetic analysis showed that the maximum concentration and area under the curve of this compound in the blood increased proportionately with the dosage, and it had a half-life of approximately 2 hours.
- In a study on mice, daily oral administration of Black Cohosh extract at doses up to 1000 mg/kg for 28 days resulted in minimal immune effects, with the exception of an increased cytotoxic T cell response. No significant effects were observed on T-dependent antibody responses or innate immunity.
Conclusion:
The research suggests that Black Cohosh extract is tolerated at certain doses without acute toxicity and has a predictable pharmacokinetic profile. However, the specific daily dosage for humans cannot be precisely determined from the available data, as the studies provided do not directly translate animal dosages to human equivalents. It is important to consult with a healthcare provider to determine the appropriate dosage for individual use, considering factors such as body weight, health status, and specific symptoms being addressed.
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