How much NAD+ Boosters should I take daily?

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Optimal Daily Dosage of NAD+ Boosters

Introduction to NAD+ Boosters

NAD+ boosters are supplements designed to increase the levels of nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme involved in various metabolic processes. As NAD+ levels decline with age, supplementation has gained attention for its potential to improve health and mitigate age-related diseases.

Recommended Dosage of Nicotinamide Riboside (NR)

Clinical Trials and Dosage Efficacy

A study involving 120 healthy adults aged 60-80 years evaluated the effects of nicotinamide riboside and pterostilbene (NRPT) on NAD+ levels. Participants were divided into three groups: placebo, recommended dose (NRPT 1X), and double dose (NRPT 2X). The recommended dose (NRPT 1X) was found to increase NAD+ levels by approximately 40%, while the double dose (NRPT 2X) resulted in a 90% increase after four weeks. These levels were sustained throughout the eight-week trial, indicating that both dosages are effective and safe for increasing NAD+ levels.

Safety and Tolerability

The study reported no serious adverse events, suggesting that both the recommended and double doses of NRPT are safe for daily consumption. Another study confirmed that oral administration of 250 mg to 1000 mg of NR per day was well tolerated, with significant increases in NAD+ levels observed.

Niacin as an NAD+ Booster

Dosage and Effects

Niacin, a form of vitamin B3, has also been studied for its NAD+ boosting properties. In a trial involving patients with mitochondrial myopathy, doses ranging from 750 mg to 1000 mg per day were administered. This resulted in an up to 8-fold increase in blood NAD+ levels and improvements in muscle performance and mitochondrial biogenesis.

Safety Considerations

While niacin was effective in increasing NAD+ levels, some patients exhibited a tendency towards anemia, indicating that higher doses may require monitoring for potential side effects.

Acipimox and Other NAD+ Precursors

Dosage and Efficacy

Acipimox, another NAD+ precursor, was tested at a dosage of 250 mg three times daily. This regimen increased mitochondrial function in skeletal muscle, demonstrating the potential of acipimox as an effective NAD+ booster.

Comparative Efficacy

A combination of nicotinamide and D-ribose (RiaGev) at a dosage of 1520 mg twice daily for seven days also significantly increased NAD+ levels and improved metabolic health markers without adverse events. However, another study found that supplementation with L-tryptophan, nicotinic acid, and nicotinamide did not significantly affect mitochondrial function or skeletal muscle function in older adults, suggesting variability in efficacy depending on the specific NAD+ precursor used.

Conclusion

Based on current research, the optimal daily dosage of NAD+ boosters varies depending on the specific supplement:

Nicotinamide Riboside (NR): 250 mg to 1000 mg per day is effective and well-tolerated .
Niacin: 750 mg to 1000 mg per day can significantly boost NAD+ levels but may require monitoring for side effects.
Acipimox: 250 mg three times daily has shown efficacy in improving mitochondrial function.
RiaGev: 1520 mg twice daily is effective and safe for increasing NAD+ levels.

It is advisable to start with the lower end of the dosage range and consult with a healthcare provider to tailor the dosage to individual health needs and monitor for any potential side effects.