How much NAD+ Boosters should I take daily?

Introduction

NAD+ (nicotinamide adenine dinucleotide) is a crucial molecule involved in various metabolic processes and is known to decline with age. NAD+ boosters, such as nicotinamide riboside (NR) and nicotinamide (NAM), are being studied for their potential to increase NAD+ levels and promote healthy aging. This synthesis aims to provide insights into the optimal daily dosage of NAD+ boosters based on recent research findings.

Key Insights

Dose-Dependent Increase in NAD+ Levels with NRPT:
- A study on NRPT (a combination of nicotinamide riboside and pterostilbene) showed that a regular dose (NRPT 1X) increased NAD+ levels by approximately 40%, while a double dose (NRPT 2X) increased levels by about 90% after four weeks. These increases were sustained over an eight-week period.
Single-Dose Nicotinamide Supplementation:
- A single dose of nicotinamide (200 mg) led to a 30-fold increase in blood nicotinamide levels within 0.5 hours, with NAD+ levels peaking at 12 hours. The effects lasted for 24 hours before returning to baseline by 48 hours.
Bioavailability and Dose-Response of Nicotinamide Riboside:
- Nicotinamide riboside (NR) was shown to be highly bioavailable, with single doses of 100, 300, and 1,000 mg producing dose-dependent increases in blood NAD+ levels. A single oral dose of NR could elevate NAD+ levels by up to 2.7-fold.

Conclusion

The research indicates that NAD+ boosters such as NRPT and nicotinamide can significantly increase NAD+ levels in a dose-dependent manner. For NRPT, a regular daily dose can increase NAD+ levels by 40%, while a double dose can achieve a 90% increase. Nicotinamide at a dose of 200 mg shows a rapid and significant increase in NAD+ levels, peaking at 12 hours and lasting for 24 hours. Nicotinamide riboside is also effective, with doses ranging from 100 to 1,000 mg showing substantial increases in NAD+ levels. Therefore, the optimal daily dosage may vary depending on the specific NAD+ booster used, but both NRPT and nicotinamide riboside have demonstrated efficacy in increasing NAD+ levels.

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How much NAD+ Boosters should I take daily?

Summary

Introduction

Key Insights

Conclusion

Sources and full results

Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study

Repeat dose NRPT (nicotinamide riboside and pterostilbene) is a safe and effective way to increase NAD+ levels in humans safely and sustainably, potentially benefiting age-related diseases.

A nonrandomized study of single oral supplementation within the daily tolerable upper level of nicotinamide affects blood nicotinamide and NAD+ levels in healthy subjects

Single-dose nicotinamide supplementation within the daily tolerable upper level (200 mg) effectively increases NAD+ levels in healthy male volunteers, warranting further clinical evaluation for potential benefits for healthy longevity.

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

A single oral dose of nicotinamide riboside can significantly increase blood NAD+ levels in humans, with a rise in NAAD being a sensitive biomarker for effective NAD+ repletion.

Niacin Cures Systemic NAD+ Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy.

Niacin effectively boosts NAD+ levels and improves muscle strength and mitochondrial biogenesis in adult-onset mitochondrial myopathy patients, reducing anemia and liver fat.

A Combination of Nicotinamide and D-Ribose (RiaGev) Is Safe and Effective to Increase NAD+ Metabolome in Healthy Middle-Aged Adults: A Randomized, Triple-Blind, Placebo-Controlled, Cross-Over Pilot Clinical Trial

RiaGev is a safe and effective supplement for increasing NAD+ metabolome in healthy middle-aged adults, potentially improving mental concentration and motivation without significant adverse events.

Evidence for a Direct Effect of the NAD+ Precursor Acipimox on Muscle Mitochondrial Function in Humans

Acipimox, an NAD+ precursor, directly affects skeletal muscle mitochondrial function in humans, despite increased NEFA levels and decreased insulin sensitivity.

NAD+-Precursor Supplementation With L-Tryptophan, Nicotinic Acid, and Nicotinamide Does Not Affect Mitochondrial Function or Skeletal Muscle Function in Physically Compromised Older Adults

NAD+-precursor supplementation with L-tryptophan, nicotinic acid, and nicotinamide does not improve mitochondrial or skeletal muscle function in physically compromised older adults.

An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers

Oral nicotinamide riboside (NR) is well-tolerated and increases circulating NAD+ levels, potentially benefiting patients with mitochondrial dysfunction due to genetic and acquired diseases.

Current Uncertainties and Future Challenges Regarding NAD+ Boosting Strategies

NAD+ boosters show promise in aging prevention and disease therapy, but more clinical trials are needed to determine proper doses, durations, and long-term safety.

Implications of NAD+ boosters in translational medicine

NAD+ boosters show potential in preserving NAD+ levels, potentially benefiting age-related diseases like cardiometabolic and neurodegenerative diseases.

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