How much DHEA should I take daily?

Introduction

Dehydroepiandrosterone (DHEA) is a naturally occurring hormone that serves as a precursor to sex steroids. Its levels decline with age, prompting research into the effects of DHEA supplementation, particularly in postmenopausal women and elderly individuals.

Key Insights from Research Papers

A daily oral dose of 50mg DHEA for 52 weeks was found to be safe, with no significant effects on lipid profile, insulin resistance, or adverse endometrial effects in postmenopausal women.
A similar dose of 50mg daily for one year did not result in harmful accumulation of DHEAS and active steroids, improved bone turnover in women over 70, increased libido parameters in older women, and improved skin status without creating "supermen/women".
Pharmacokinetic studies suggest that daily oral administration of DHEA at doses of 25mg and 50mg is safe in elderly subjects, with no worrying transformation to androgen and estrogen.
A higher dose of 100mg daily for six months was studied, but the abstract does not provide safety or efficacy outcomes.
Intravaginal administration of a low dose (6.5mg) of DHEA for 12 weeks kept serum steroid concentrations within normal postmenopausal values, indicating local efficacy without systemic exposure.
A daily dose of 50mg DHEA did not significantly affect the urine testosterone/epitestosterone ratio, suggesting minimal impact on androgenic activity.
A lower dose of 10mg/day DHEA for one year was effective in replacing androgen deficiency in postmenopausal women with reduced baseline levels of Delta-5 androgens.

Conclusion

The research suggests that a daily dose of 50mg DHEA is generally safe and can provide various benefits such as improved bone turnover, libido, and skin health in older adults, particularly postmenopausal women. Lower doses, such as 10mg/day, may be sufficient for androgen replacement in certain populations. Higher doses, like 100mg daily, have been studied, but safety and efficacy data are not detailed in the provided abstracts. Intravaginal administration of 6.5mg DHEA also appears to be safe and effective for local treatment without systemic effects. It is important to note that individual responses to DHEA supplementation can vary, and the optimal dose may depend on specific health goals and individual health status.

How much DHEA should I take daily?

Summary

Introduction

Key Insights from Research Papers

Conclusion

Sources and full results

The safety of 52 weeks of oral DHEA therapy for postmenopausal women.

Oral DHEA 50mg daily for 52 weeks did not significantly alter lipid profile, insulin sensitivity, or adversely affect the endometrium in postmenopausal women.

Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution of the DHEAge Study to a sociobiomedical issue.

DHEA replacement therapy, 50 mg/day for a year, can normalize some effects of aging without creating "supermen/women," but does not create "supermen/women" through doping.

Dehydroepiandrosterone replacement administration: pharmacokinetic and pharmacodynamic studies in healthy elderly subjects.

Daily oral administration of DHEA (25/50 mg) is safe in elderly subjects, with no accumulation of steroids or concerns about androgen and estrogen transformation.

The effect of six months treatment with a 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex steroids, body composition and muscle strength in age‐advanced men and women

A 100 mg daily dose of DHEA for six months improved circulating sex steroids, body composition, and muscle strength in age-advanced men and women, with no significant adverse effects observed.

Serum steroid concentrations remain within normal postmenopausal values in women receiving daily 6.5mg intravaginal prasterone for 12weeks

Daily intravaginal 6.5mg of DHEA (prasterone) effectively treats vulvovaginal atrophy symptoms without causing systemic exposure, in line with menopause mechanisms.

The effect of oral dehydroepiandrosterone (DHEA) on the urine testosterone/epitestosterone (T/E) ratio in human male volunteers.

Oral DHEA at 50 mg daily for 30 days has minimal effect on urine testosterone/epitestosterone ratios and does not result in a positive screen for testosterone abuse.

One-year therapy with 10mg/day DHEA alone or in combination with HRT in postmenopausal women: effects on hormonal milieu.

10mg/day DHEA is the proper dose to replace androgen deficiency in postmenopausal women with reduced Delta-5 androgens levels, but aging and years since menopause may further modulate hormone therapy effects.

Salivary cortisol and DHEA: association with measures of cognition and well-being in normal older men, and effects of three months of DHEA supplementation

DHEA supplementation showed no significant short-term benefits for cognition or well-being in normal older men.

Changes in serum DHEA and eleven of its metabolites during 12-month percutaneous administration of DHEA

Percutaneous DHEA administration for 12 months may overestimate androgen formation and estrogen production in postmenopausal women, while serum DHEA levels remain stable.

Effect of intravaginal DHEA on serum DHEA and eleven of its metabolites in postmenopausal women

Intravaginal DHEA rapidly improves vaginal atrophy without significantly changing serum estrogens, avoiding the increased risk of breast cancer associated with current estrogenic formulations.

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