How much Hemp CBD should I take daily?
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Optimal Daily Dosage of Hemp CBD
Introduction to Hemp CBD Dosage
Hemp-derived cannabidiol (CBD) has gained popularity for its potential therapeutic benefits, particularly in managing inflammatory conditions and pain. Determining the optimal daily dosage of CBD is crucial for maximizing its benefits while ensuring safety.
Dosage Insights from Canine Studies
Liposomal vs. Non-Liposomal CBD
Research involving canine models of osteoarthritis has provided valuable insights into effective CBD dosages. A study demonstrated that liposomal CBD at 20 mg/day was as effective as 50 mg/day of non-liposomal CBD in reducing pain and improving mobility in dogs . This suggests that liposomal formulations, which enhance bioavailability, may allow for lower dosages while achieving similar therapeutic effects.
Dose-Dependent Effects
The same study highlighted a dose-dependent response, where higher doses of CBD led to greater improvements in clinical outcomes . This indicates that the optimal dosage may vary based on the severity of the condition being treated.
Pharmacokinetics and Long-Term Use
Accumulation and Metabolism
Long-term studies on dogs have shown that CBD accumulates in the body over time. In a 36-week study, dogs receiving 5 and 10 mg/kg/day of CBD exhibited significant increases in plasma CBD levels, suggesting dose-proportional accumulation. This accumulation was accompanied by an increased half-life and mean residence time, indicating that CBD remains in the system longer with chronic use.
Frequency of Administration
The same study suggested that administering CBD twice daily might reduce daily variations in plasma levels, potentially leading to more consistent therapeutic effects.
Human Implications
Translating Animal Data to Human Dosage
While these studies provide a foundation, translating animal dosages to humans requires careful consideration. The effective dosages in dogs (20-50 mg/day) may not directly apply to humans due to differences in metabolism and body weight. However, these findings support the potential for lower dosages of liposomal CBD to achieve similar effects as higher dosages of non-liposomal CBD.
Safety and Efficacy
The studies also confirmed the safety of CBD, with no significant detrimental impacts observed over the study periods . This supports the feasibility of long-term CBD use, provided that dosages are adjusted based on individual responses and conditions.
Conclusion
Determining the optimal daily dosage of hemp CBD involves considering factors such as formulation type, condition severity, and individual metabolism. Studies in canine models suggest that liposomal CBD at 20 mg/day can be as effective as higher doses of non-liposomal CBD, and that chronic use leads to accumulation in the body. For humans, starting with lower dosages and adjusting based on response and formulation type may be a prudent approach. Further research in human subjects is warranted to refine these recommendations.
Sources and full results
Most relevant research papers on this topic
A randomized, double-blind, placebo-controlled study of daily cannabidiol for the treatment of canine osteoarthritis pain.
A Randomized, Double-Blind, Placebo-Controlled Study of Daily Cannabidiol for the Treatment of Canine Osteoarthritis
Pharmacokinetics of cannabidiol-/cannabidiolic acid-rich hemp oil in juvenile cynomolgus macaques (Macaca fascicularis)
Cannabidiol plasma determination and pharmacokinetics conducted at beginning, middle and end of long-term supplementation of a broad-spectrum hemp oil to healthy adult dogs
Single-Dose Pharmacokinetics and Preliminary Safety Assessment with Use of CBD-Rich Hemp Nutraceutical in Healthy Dogs and Cats
Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model
A Novel Self-Emulsifying Drug Delivery System (SEDDS) Based on VESIsorb® Formulation Technology Improving the Oral Bioavailability of Cannabidiol in Healthy Subjects
A systematic review of cannabidiol dosing in clinical populations
Serum Cannabinoid 24 h and 1 Week Steady State Pharmacokinetic Assessment in Cats Using a CBD/CBDA Rich Hemp Paste
Effects of Hemp Extract on Markers of Wellness, Stress Resilience, Recovery and Clinical Biomarkers of Safety in Overweight, But Otherwise Healthy Subjects
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