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These studies suggest a daily dose of 600 mg to 1200 mg of St. John's Wort extract is effective for treating mild to moderate major depression.
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St. John's Wort (Hypericum perforatum) is a popular herbal remedy commonly used for the treatment of depression. The appropriate daily dosage of St. John's Wort for effective treatment and safety is a critical consideration for users and healthcare providers.
Effective Dosage for Depression:
Safety and Efficacy:
Interaction with Other Medications:
For the treatment of mild to moderate major depression, a daily dosage of 600 mg to 1200 mg of St. John's Wort extract (WS® 5570) is recommended. The higher dose of 1200 mg/day may offer better remission rates. Additionally, a St. John's Wort extract with low hyperforin content (250 mg twice daily) appears to have minimal interaction with low-dose oral contraceptives, suggesting it is safe to use alongside such medications.
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