How much Kratom should I take daily?

Introduction

Kratom (Mitragyna speciosa Korth.) is a medicinal plant native to Southeast Asia, traditionally used for its stimulant and opioid-like effects. The appropriate daily dosage of kratom remains a topic of interest due to its varying effects on cognitive function, biochemical parameters, and potential health risks.

Key Insights

Cognitive Function and Kratom Use:
- Higher consumption of kratom (>3 glasses daily or mitragynine doses between 72.5 mg and 74.9 mg) is associated with selective impairments in visual episodic memory and new learning, but does not significantly affect motor, memory, attention, or executive function.
Motives for Kratom Use:
- Heavy kratom use (>3 glasses daily, each glass containing 48.24-50.4 mg of mitragynine) is often associated with coping and enhancement motives. Higher consumption is linked to higher scores on coping domains, especially among single individuals and those with higher income.
Biochemical and Safety Parameters:
- Continuous consumption of kratom at a daily mitragynine dose of 76.3-114.8 mg does not significantly alter safety hematological and biochemical parameters, except for a decrease in white cell count and changes in lipid profiles. Kidney, liver function tests, thyroid, and glucose parameters remain within normal ranges.
Cardiovascular Effects:
- Regular kratom use, with an estimated average daily intake of 434.28 mg of mitragynine, is not associated with significant electrocardiographic abnormalities, except for higher odds of sinus tachycardia and borderline QTc intervals. There is no increased risk of prolonged QTc intervals compared to non-users.

Conclusion

The appropriate daily dosage of kratom varies based on individual needs and health conditions. For cognitive function, doses above 3 glasses daily (72.5-74.9 mg of mitragynine) may impair certain memory functions. Heavy use is often driven by coping and enhancement motives. Biochemically, daily doses up to 114.8 mg appear safe, with no significant adverse effects on major health parameters. Cardiovascularly, even higher doses (up to 434.28 mg) do not show significant ECG abnormalities, though there is a risk of sinus tachycardia. Users should consider these factors and consult healthcare professionals for personalized advice.

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Summary

Introduction

Key Insights

Conclusion

Sources and full results

Long-Term Cognitive Effects of Kratom (Mitragyna speciosa Korth.) Use

Higher consumption of kratom tea (>3 glasses daily) is associated with impaired visual episodic memory and new learning, but does not impair motor, memory, attention, or executive function in regular users.

Motives for using Kratom (Mitragyna speciosa Korth.) among regular users in Malaysia.

High kratom consumption (>3 glasses daily) is associated with coping and enhancement motives among regular users in traditional, rural settings in Malaysia.

Comparison of biochemical and safety parameters of regular kratom (Mitragyna speciosa Korth.) users at two different time periods

Continuous consumption of kratom decoction at a daily mitragynine dose of 76.3-114.8 mg does not significantly alter the safety hematological and biochemical parameters of users.

Is kratom (Mitragyna speciosa Korth.) use associated with ECG abnormalities? Electrocardiogram comparisons between regular kratom users and controls

Regular kratom use is not linked to electrocardiographic abnormalities, with an estimated average daily intake of 434.28 mg of mitragynine.

Kratom (Mitragyna speciosa) dependence, withdrawal symptoms and craving in regular users.

Regular Kratom use is associated with drug dependency, withdrawal symptoms, and craving, with more severe symptoms occurring with prolonged use.

Effects of Kratom (Mitragyna Speciosa Korth.) Use in Regular Users

Kratom use produces both stimulant and sedative effects, but these effects are not significantly associated with the dose consumed, both among short-term and long-term users.

Evaluating the hematological and clinical-chemistry parameters of kratom (Mitragyna speciosa) users in Malaysia.

Long-term and heavy kratom consumption did not significantly alter hematological and clinical-chemistry parameters in traditional Malaysian settings.

Searching for a Signal: Self-Reported Kratom Dose-Effect Relationships Among a Sample of US Adults With Regular Kratom Use Histories

Kratom use is common among US adults, with most experiencing acute effects within hours, and more weeks of regular use predicts greater severity of unwanted effects from cessation.

Reversal of Hepatomegaly Following Cessation of Kratom Consumption in C57BL/6 Male and Female Mice

Kratom consumption for 10 days causes hepatomegaly in mice, which can be reversed after 30 days of discontinuance.

Kratom (Mitragyna speciosa): User demographics, use patterns, and implications for the opioid epidemic.

Kratom is used by White, middle-aged Americans for pain, anxiety, depression, and opioid withdrawal, with regular use and mild adverse effects, but kratom-related substance use disorders and serious adverse effects are uncommon.

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