How Much Licorice Root Should I Take Daily?

Research Analysis by Consensus

Consensus Meter

Yes

Possibly

Recommended Daily Intake of Licorice Root

Glycyrrhizin Content and Safety Assessment

Licorice root, known for its extensive use in foods, traditional medicine, and herbal remedies, contains glycyrrhizin as its principal active component. The safety and risk assessment of glycyrrhizin consumption have been thoroughly studied. Regulatory agencies have approved its use in foods, with an estimated daily intake ranging from 0.027 to 3.6 mg glycyrrhizin per kilogram of body weight. However, continuous high-level exposure to glycyrrhizin can lead to hypermineralocorticoid-like effects, which are reversible upon discontinuation.

Acceptable Daily Intake

Based on various in vivo and clinical studies, an acceptable daily intake (ADI) of glycyrrhizin has been proposed. The recommended ADI is between 0.015 and 0.229 mg glycyrrhizin per kilogram of body weight per day. This range is considered safe and accounts for the potential pharmacological and toxicological effects of glycyrrhizin.

Clinical Trial on Licorice Root Supplementation

A clinical trial evaluated the effects of licorice root supplementation on women with nonalcoholic fatty liver disease (NAFLD). Participants were given 1,000 mg of licorice root extract daily for 12 weeks. The study found significant improvements in liver enzymes, insulin resistance, oxidative stress parameters, and liver steatosis compared to the placebo group. This suggests that a daily intake of 1,000 mg of licorice root extract can be beneficial for specific health conditions when combined with lifestyle modifications.

Conclusion

In summary, the recommended daily intake of licorice root should be guided by the glycyrrhizin content. An acceptable daily intake of glycyrrhizin is between 0.015 and 0.229 mg per kilogram of body weight. For specific health conditions like NAFLD, a daily intake of 1,000 mg of licorice root extract has shown beneficial effects. Always consult with a healthcare provider before starting any new supplementation regimen to ensure safety and appropriateness for your individual health needs.

Research Analysis by Consensus

Consensus Meter

Recommended Daily Intake of Licorice Root

Glycyrrhizin Content and Safety Assessment

Acceptable Daily Intake

Clinical Trial on Licorice Root Supplementation

Conclusion

Sources and full results

Risk and safety assessment on the consumption of Licorice root (Glycyrrhiza sp.), its extract and powder as a food ingredient, with emphasis on the pharmacology and toxicology of glycyrrhizin.

Effects of licorice root supplementation on liver enzymes, hepatic steatosis, metabolic and oxidative stress parameters in women with nonalcoholic fatty liver disease: A randomized double‐blind clinical trial

Effects of prolonged ingestion of graded doses of licorice by healthy volunteers.

Effects of dried licorice extract with low-calorie diet on lipid profile and atherogenic indices in overweight and obese subjects: A randomized controlled clinical trial

Efficacy of oral administration of licorice as an adjunct therapy on improving the symptoms of patients with Parkinson's disease, A randomized double blinded clinical trial.

Dietary licorice root supplementation reduces diet-induced weight gain, lipid deposition, and hepatic steatosis in ovariectomized mice without stimulating reproductive tissues and mammary gland.

Antiatherosclerotic effects of licorice extract supplementation on hypercholesterolemic patients: increased resistance of LDL to atherogenic modifications, reduced plasma lipid levels, and decreased systolic blood pressure.

The Efficacy of Licorice Root Extract in Decreasing Transaminase Activities in Non‐alcoholic Fatty Liver Disease: A Randomized Controlled Clinical Trial

Metabolic changes after licorice consumption: A systematic review with meta-analysis and trial sequential analysis of clinical trials.

Effect of liquorice and glycyrrhizin on rat liver carcinogen metabolizing enzymes.

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