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These studies suggest that while mangosteen juice may reduce certain inflammation markers in obese individuals, it does not significantly alleviate physical fatigue during exercise, and there is no specific recommended daily amount provided.
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Mangosteen juice, derived from the Garcinia mangostana fruit, is renowned for its potential health benefits, including anti-inflammatory and antioxidant properties. This article synthesizes findings from recent studies to determine the optimal daily dosage of mangosteen juice for health benefits.
A pilot study evaluated the effects of different dosages of a proprietary mangosteen juice blend (XanGo Juice™) on inflammation markers in obese individuals with elevated C-reactive protein (CRP) levels. Participants were divided into four groups: placebo, 3 oz, 6 oz, and 9 oz of juice taken twice daily (totaling 6 oz, 12 oz, and 18 oz per day, respectively) over an 8-week period. The study found that the highest dose of 18 oz per day significantly reduced CRP levels compared to the placebo group (p = 0.02). Other markers of inflammation and lipid peroxidation did not show significant differences, but there was a trend towards a decrease in BMI in the juice groups.
The study also reported no side effects in any of the groups, and safety assessments, including laboratory and EKG evaluations, indicated no clinically significant changes for any subject. This suggests that up to 18 oz of mangosteen juice per day is safe for consumption.
Another study investigated the effect of acute mangosteen supplementation on physical fatigue during exercise. In this randomized, double-blind, placebo-controlled, crossover trial, 12 healthy adults consumed 250 mL of mangosteen-based juice (containing 305 mg of α-mangostin and 278 mg of hydroxycitric acid) or a placebo 1 hour before exercise. The study found no significant differences in physical fatigue parameters between the mangosteen and placebo groups, except for a positive impact on the Profile of Mood States (POMS) examination. This indicates that while mangosteen juice may not alleviate physical fatigue, it could have mood-enhancing effects.
Based on the available research, a daily intake of up to 18 oz of mangosteen juice appears to be safe and may provide anti-inflammatory benefits, particularly for individuals with elevated CRP levels. However, for acute physical fatigue, mangosteen juice does not seem to offer significant benefits. Further studies with larger populations are needed to confirm these findings and better understand the full range of health benefits associated with mangosteen juice consumption.
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