How much Spermidine should I take daily?
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Summary
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These studies suggest that while spermidine supplementation can increase spermine levels in plasma and is safe and well-tolerated, they do not provide specific guidance on the daily amount that should be taken.
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Daily Spermidine Supplementation: Recommended Dosage and Safety
Introduction to Spermidine Supplementation
Spermidine is a naturally occurring polyamine that plays a significant role in cellular metabolism and has been linked to various health benefits, including the potential to delay age-related diseases. As spermidine levels decline with age, supplementation has been proposed as a preventive measure.
Recommended Dosage of Spermidine
Current research on the optimal dosage of spermidine supplementation is still evolving. A study investigating the pharmacokinetics of spermidine supplementation administered 15 mg per day to healthy adults. The results indicated that this dosage significantly increased spermine levels in the plasma but did not affect spermidine or putrescine levels in the blood or saliva. This suggests that spermidine is converted into spermine, which then circulates in the bloodstream.
Another study focused on the safety and tolerability of spermidine supplementation in older adults with subjective cognitive decline. In this study, participants were given a spermidine-rich plant extract at a dosage of 1.2 mg per day for three months. The results showed no adverse effects, indicating that this lower dosage is safe and well-tolerated.
Safety and Tolerability
The safety profile of spermidine supplementation has been evaluated in both animal and human studies. In a preclinical study, mice were given spermidine for 28 days, and no morbidities or behavioral changes were observed. Post-mortem examinations also showed no increase in tumorigenic or fibrotic events.
In a human trial involving older adults, a 1.2 mg daily dosage of spermidine was found to be safe over a three-month period. No significant differences were observed between the spermidine and placebo groups in terms of vital signs, weight, clinical chemistry, hematological parameters, or self-reported health status. Compliance rates were above 85%, indicating excellent tolerability.
Conclusion
Based on current research, a daily dosage of 1.2 mg of spermidine appears to be safe and well-tolerated in older adults. Higher doses, such as 15 mg per day, have been shown to affect plasma spermine levels but require further investigation to confirm their long-term safety and efficacy. As always, it is advisable to consult with a healthcare provider before starting any new supplementation regimen.
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