Modern thiamine deficiency rates range from 20% to over 90%, suggesting the RDA may be insufficient to meet modern living demands.

Hiding in Plain Sight: Modern Thiamine Deficiency

Vitamin B1 deficiency can cause nerve, visual, and heart problems, and should be addressed with a daily 0.4 mg dose per 1000 kcal.

Vitamin B1, eye and brain

Thiamine deficiency can be observed at intakes below 0.5 mg/day, with a lower limit of intake at 0.05 mg/MJ, and a higher requirement for pregnant and lactating women and elderly individuals.

Thiamin (Vitamin B1) – A scoping review for Nordic Nutrition Recommendations 2023

High-dose thiamine therapy reduces liver fat in sheep under overnutrition conditions, but has no effect on body weight or blood glucose, but may increase fatty acid utilization as a source of energy.

Metabolic Effects of Vitamin B1 Therapy under Overnutrition and Undernutrition Conditions in Sheep

High doses of parenteral thiamine can prevent Wernicke's encephalopathy in patients with kidney disease and severe malnutrition.

Wernicke's encephalopathy in acute and chronic kidney disease: a systematic review.

High-dose thiamine supplementation (100 mg/day) can help prevent and accelerate recovery from exercise-induced fatigue in male athletes.

Effects of thiamine supplementation on exercise-induced fatigue

The dose of thiamine supplementation in lactating women in Cambodia needs to be determined to optimize infant thiamine levels and combat thiamine deficiency.

Thiamine dose response in human milk with supplementation among lactating women in Cambodia: study protocol for a double-blind, four-parallel arm randomised controlled trial

Thiamine deficiency contributes to neurodegenerative diseases, and supporting vitamin B1 therapy can have a favourable impact on advanced neurodegenerative diseases like Parkinson's, Alzheimer's, Wernicke's encephalopathy, and Huntington's disease.

[The role of thiamine in neurodegenerative diseases].

The optimal daily intake of thiamine for a moderately active man consuming 3000 calories is not universally agreed upon, with various criteria used to determine the minimum requirements.

STUDIES OF THIAMINE METABOLISM IN MAN. I. THIAMINE BALANCE. THE NORMAL REQUIREMENT OF VITAMIN B(1) AND THE ROLE OF FECAL THIAMINE IN HUMAN NUTRITION.

The EFSA Panel endorses the average requirement of 0.072 mg/MJ (0.3 mg/1,000 kcal) for adults and endorses the population reference intake of 0.1 mg/MJ (0.4 mg/1,000 kcal) for all adults, infants, children, and during pregnancy and lactation.

Dietary reference values for thiamin

Thiamine deficiency is common in alcohol dependence patients, and treatment can prevent cognitive impairments and Wernicke's encephalopathy.

[Thiamine (vitamin B1) treatment in patients with alcohol dependence].

Postoperative dietary intakes of both thiamin and vitamin B6 are inadequate for maintaining normal enzyme activities in morbidly obese females after gastroplasty.

Thiamin and vitamin B6 intakes and erythrocyte transketolase and aminotransferase activities in morbidly obese females before and after gastroplasty.

The average daily intake of vitamin B1 in Egypt is 1.0 mg, with 70% of it derived from bread and other cereal products.

Vitamin B1 profile of the Egyptian core foods and adequacy of intake

Thiamine deficiency is common in alcohol dependence patients, leading to cognitive impairments and Wernicke's encephalopathy.

Le traitement par thiamine (vitamine B1) dans l’alcoolodépendance

Vitamin B1 deficiency may have a potential causal relationship with eclampsia, as it is associated with beriberi and pellagra in various regions.

Vitamin B1 deficiency as an etiologic factor in pregnancy toxemias: Part II

Thiamine supplementation improves clinical symptoms in patients with refeeding syndrome and has no harmful outcomes.

A Systematic Review of the Role of Thiamine Supplementation in Treatment of Refeeding Syndrome

Thiamine deficiency is common in Asia and Africa, affecting up to a third of children and women of child-bearing age, with treatment being safe and effective.

Thiamine deficiency disorders in women and children

Thiamine deficiency during pregnancy and lactation can cause rare neurological and cardio-pulmonary manifestations, highlighting the need for increased vitamin B1 intake during these periods.

A case series of rare neurological and cardio-pulmonary manifestations of thiamine deficiency in pregnancy and lactation

A high percentage of the Spanish population meets EFSA recommended intakes for thiamin (71.2%), riboflavin (72.0%), niacin (99.0%), and vitamin B6 (77.2%).

Dietary Intake and Food Sources of Niacin, Riboflavin, Thiamin and Vitamin B6 in a Representative Sample of the Spanish Population. The ANIBES Study †

A daily vitamin B-12 intake of 6 microg is sufficient to correct all vitamin B-12-related variables in postmenopausal Danish women.

A daily intake of approximately 6 microg vitamin B-12 appears to saturate all the vitamin B-12-related variables in Danish postmenopausal women.

How much Vitamin B1 (Thiamine) should I take daily?

These studies suggest a daily intake of 0.4 mg of Vitamin B1 (Thiamine) per 1000 kcal, with higher needs for pregnant, lactating women, and elderly individuals.