Multi collagen peptides
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Multi Collagen Peptides: Applications and Benefits
Introduction to Multi Collagen Peptides
Multi collagen peptides are short chains of amino acids derived from collagen, the most abundant protein in the animal kingdom. These peptides mimic the structure and function of natural collagen, making them valuable in various biomedical and cosmetic applications. They are known for their ability to self-assemble into complex structures, improve skin health, aid in wound healing, and support joint and bone health.
Self-Assembly and Structural Properties
Collagen Mimetic Peptides and Nanofibres
Collagen mimetic peptides can replicate the multi-hierarchical self-assembly of natural collagen, transitioning from peptide chains to triple helices, then to nanofibres, and finally forming hydrogels. This process is stabilized by specific amino acid sequences and salt-bridged hydrogen bonds, resulting in nanofibres that degrade at rates similar to natural collagen 1. These properties make them suitable for tissue engineering and other biomedical applications.
Synthetic Collagen-Like Polymers
Synthetic collagen-like polymers, created through end-to-end disulfide cross-linking, exhibit gel-forming properties and can be tailored for specific biological functions. These materials can be shaped into various forms, such as thin films, and have tunable biodegradability and bioactivity, making them versatile for use in biocompatible materials 5.
Skin Health Benefits
Oral Collagen Peptide Supplementation
Oral intake of collagen peptides has been shown to significantly improve skin hydration, elasticity, desquamation, and reduce wrinkling. In a study involving women aged 30 to 60, daily intake of 1650 mg of collagen peptides for 12 weeks resulted in noticeable improvements in skin health without any side effects 2. These benefits are attributed to the bioactive peptides, such as Gly-Pro and Pro-Hyp, present in the collagen hydrolysate.
Photoaging Skin Repair
Collagen peptides also play a role in repairing photoaged skin by activating the TGF-β/Smad pathway, promoting procollagen synthesis, and inhibiting collagen degradation. Specific peptides like Ile-Hyp and Ala-Hyp-Gly have been identified as active components that enhance collagen synthesis and antioxidant defense, making them effective in anti-photoaging treatments 3.
Joint and Bone Health
Collagen Peptides and Exercise
Collagen peptide supplementation, combined with exercise, has been found to improve joint functionality, reduce joint pain, and support recovery from joint injuries. It also aids in muscle recovery and enhances collagen synthesis, although it does not significantly impact muscle protein synthesis compared to higher quality protein sources 4. This makes collagen peptides beneficial for managing degenerative bone and joint disorders.
Wound Healing
Accelerated Wound Healing
Collagen peptides derived from sources like Salmon and Tilapia skin have been shown to accelerate wound healing by modulating the cutaneous microbiome and inflammatory responses. These peptides up-regulate factors like NOD2 and BD14, which are crucial for wound healing, and promote angiogenesis and collagen deposition 9. This highlights their potential in developing effective wound care treatments.
Conclusion
Multi collagen peptides offer a wide range of benefits, from enhancing skin health and accelerating wound healing to supporting joint and bone health. Their ability to mimic natural collagen's structure and function makes them valuable in both biomedical and cosmetic applications. As research continues, the potential for these peptides to be used in innovative treatments and products will likely expand, offering new solutions for health and wellness.
Sources and full results
Most relevant research papers on this topic
Multi-hierarchical self-assembly of a collagen mimetic peptide from triple helix to nanofibre and hydrogel.
This study successfully replicates the multi-hierarchical self-assembly of collagen through triple helix, nanofibres, and hydrogel, offering potential biomedical applications in tissue engineering.
Highly CitedOral intake of collagen peptide NS improves hydration, elasticity, desquamation, and wrinkling in human skin: a randomized, double-blinded, placebo-controlled study.
Oral intake of collagen peptide NS, containing Gly-Pro and Pro-Hyp, significantly improves skin hydration, elasticity, desquamation, and wrinkling in women aged 30 to 60 years without causing side effects.
RCTCollagen peptides promote photoaging skin cell repair by activating the TGF-β/Smad pathway and depressing collagen degradation.
Collagen peptides promote photoaging skin cell repair by activating the TGF-/Smad pathway and depressing collagen degradation, with SHCP showing the strongest bioactivity.
In Vitro StudyThe effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic review
Collagen peptide supplementation, combined with exercise, improves joint functionality, reduces joint pain, and enhances body composition, strength, and muscle recovery.
Systematic ReviewDevelopment of a collagen-like peptide polymer via end-to-end disulfide cross-linking and its application as a biomaterial.
This study developed a novel synthetic collagen-like peptide polymer that mimics native collagen's properties and biological functions, offering potential as a biocompatible material with customizable gel stiffness, bioactivities, and biodegradability.
In Vitro StudyThe effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo‐controlled clinical trials
Oral collagen peptide supplementation improves skin hydration and the dermal collagen network in a clinical setting, potentially reducing skin dryness and aging-related skin issues.
RCT
Rigorous JournalHighly CitedExploration of collagen recovered from animal by-products as a precursor of bioactive peptides: Successes and challenges
Collagen peptides, recovered from animal by-products, show potential as high value-added bio-functional ingredients in the food industry due to their antihypertensive, antioxidant, and antidiabetic activities.
Highly CitedMulticomponent peptide assemblies.
Multicomponent peptide assemblies show potential as sophisticated next-generation bio-inspired materials with unique emergent properties for applications in biomedicine and energy.
Highly CitedCollagen peptides isolated from Salmon salar and Tilapia nilotica skin accelerate wound healing by altering cutaneous microbiome colonization via up-regulated NOD2 and BD14.
Collagen peptides from Salmon salar and Tilapia nilotica skin accelerate wound healing by altering cutaneous microbiome colonization and promoting healing by controlling inflammation and increasing angiogenesis and collagen deposition.
Non-RCT
Animal StudyHighly Cited