Is Mushroom Extracts safe?

Introduction

Mushroom extracts have been traditionally used in food and folk medicine, and their potential health benefits have garnered significant interest in recent years. However, the safety of these extracts, especially when used as supplements or in medicinal contexts, remains a critical area of investigation. This synthesis aims to evaluate the safety of mushroom extracts based on findings from multiple research studies.

Key Insights

General Safety and Side Effects:
- Mushroom extracts are generally considered safe for use, with some side effects that are typically reversible upon discontinuation of intake .
Safety in Cosmeceutical Applications:
- Ethanolic extracts from mushrooms like Ganoderma lucidum and Pleurotus ostreatus have shown no toxicity in keratinocytes and fibroblasts, indicating their safety for use in skin care products.
Safety in Cardiovascular Conditions:
- Psilocybin-containing mushrooms (e.g., Psilocybe cubensis and Panaeolus cyanescens) did not exacerbate pathological hypertrophy or cell injury in cardiomyocytes, suggesting safe use under controlled conditions.
Potential Toxicity Concerns:
- There is a potential risk of toxic metal contamination (e.g., arsenic, lead, cadmium, mercury) and radioactive contamination in some mushroom extracts, necessitating careful sourcing and testing.
Clinical Trials and Human Studies:
- Clinical trials involving mixed extracts of mushrooms (e.g., Grifola frondosa, Phellinus linteus, Cordyceps sinensis) have shown safety and improved quality of life in cancer patients and elderly individuals.

Conclusion

Overall, mushroom extracts appear to be safe for use in various applications, including dietary supplements and cosmeceuticals, with some minor and reversible side effects. However, potential contamination with toxic metals and the need for more well-designed human trials highlight the importance of careful sourcing and further research to ensure safety.

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Is Mushroom Extracts safe?

Summary

Consensus Meter

Introduction

Key Insights

Conclusion

Sources and full results

A review of mushrooms in human nutrition and health

Mushrooms are safe for human use, but more well-designed trials are needed to confirm their efficacy and potential health benefits.

Mushroom ethanolic extracts as cosmeceuticals ingredients: Safety and ex vivo skin permeation studies.

Mushroom ethanolic extracts are safe and effective as skin care ingredients, with protocatechuic and syringic acids showing the highest skin penetration.

Mushrooms, Tumors, and Immunity: An Update

Mushroom extracts show potential in enhancing immune function and promoting health, but further evidence-based research is needed to confirm their safety and effectiveness in oral administration to animals and humans.

Edible Mushrooms for Sustainable and Healthy Human Food: Nutritional and Medicinal Attributes

Edible mushrooms are a sustainable and healthy food source with potential health benefits, including anticancer, antidiabetic, and antiviral effects, and can be used to treat various human diseases.

Effects and safety of Psilocybe cubensis and Panaeolus cyanescens magic mushroom extracts on endothelin-1-induced hypertrophy and cell injury in cardiomyocytes

Psilocybe cubensis and Panaeolus cyanescens magic mushroom extracts do not aggravate endothelin-1-induced hypertrophy and protect against TNF--induced cell injury in cardiomyocytes, supporting their medicinal safe use under controlled conditions.

Treasures from the forest: Evaluation of mushroom extracts as anti-cancer agents.

Mushroom extracts from 92 species can reduce the viability of 38 different cancers, with breast cancer being the most sensitive, through inhibition of cancer cell proliferation, improved immune response, and inducing apoptosis.

Anti-inflammatory properties of edible mushrooms: A review.

Edible mushrooms are rich in anti-inflammatory components, offering therapeutic and health-promoting benefits, making them a valuable constituent of the daily diet for diseases associated with inflammation.

Safety and Usefulness of Fucoidan and Mushroom Extracts: an Open Clinical Trial

Fucoidan and mushroom extracts, when mixed, significantly improve quality of life for cancer patients and elderly individuals, while maintaining safety.

Medicinal Mushroom Extracts Possess Differential Antioxidant Activity and Cytotoxicity to Cancer Cells.

Hexane extracts from medicinal mushrooms show the highest cytotoxicity against cancer cells, with nonpolar or intermediate polarity solvents being more potent than high polarity solvents.

Cytotoxicity of blended versus single medicinal mushroom extracts on human cancer cell lines: contribution of polyphenol and polysaccharide content.

Blended medicinal mushroom extracts show stronger cytotoxic effects on human tumor cell lines compared to single mushroom extracts, contributing to their potential health benefits and prevention of various human pathological aberrations.

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