Mushrooms are safe for human use, but more well-designed trials are needed to confirm their efficacy and potential health benefits.

A review of mushrooms in human nutrition and health

Mushroom ethanolic extracts are safe and effective as skin care ingredients, with protocatechuic and syringic acids showing the highest skin penetration.

Mushroom ethanolic extracts as cosmeceuticals ingredients: Safety and ex vivo skin permeation studies.

Mushroom extracts and their metabolites show promising potential as cosmeceutical and nutricosmetic ingredients, offering anti-inflammatory, antioxidant, and photoprotective properties, but long-term studies are needed for major breakthroughs.

Role of bioactive compounds and other metabolites from mushrooms against skin disorders- a systematic review assessing their cosmeceutical and nutricosmetic outcomes.

This study developed a multifaceted approach to evaluate the safety of non-culinary fungi for human consumption, potentially replacing conventional toxicological animal studies.

Safety assessment of mushrooms in dietary supplements by combining analytical data with in silico toxicology evaluation.

Medicinal mushrooms have potential pharmacological properties, but more controlled experiments and clinical trials are needed to confirm their effectiveness and potential harm.

Are mushrooms medicinal?

Edible mushrooms show potential health benefits, including immune modulation and anti-tumor effects, due to their polysaccharide content, which enhances cellular immunity through T helper cell balance and interleukins.

The role of edible mushrooms in health: Evaluation of the evidence

Psilocybe cubensis and Panaeolus cyanescens magic mushroom extracts do not aggravate endothelin-1-induced hypertrophy and protect against TNF--induced cell injury in cardiomyocytes, supporting their medicinal safe use under controlled conditions.

Effects and safety of Psilocybe cubensis and Panaeolus cyanescens magic mushroom extracts on endothelin-1-induced hypertrophy and cell injury in cardiomyocytes

Mushroom extracts show potential in enhancing immune function and promoting health, but further evidence-based research is needed to confirm their safety and effectiveness in oral administration to animals and humans.

Mushrooms, Tumors, and Immunity: An Update

Essential oils and plant extracts can extend the postharvest shelf life of edible mushrooms, improving their quality and reducing microbial populations.

Advances in the Role and Mechanisms of Essential Oils and Plant Extracts as Natural Preservatives to Extend the Postharvest Shelf Life of Edible Mushrooms

Mushroom extracts from 92 species can reduce the viability of 38 different cancers, with breast cancer being the most sensitive, through inhibition of cancer cell proliferation, improved immune response, and inducing apoptosis.

Treasures from the forest: Evaluation of mushroom extracts as anti-cancer agents.

Edible mushrooms are a sustainable and healthy food source with potential health benefits, including anticancer, antidiabetic, and antiviral effects, and can be used to treat various human diseases.

Edible Mushrooms for Sustainable and Healthy Human Food: Nutritional and Medicinal Attributes

Mushroom antimicrobials show potential in food production, processing, and preservation, offering a biosolution to meet increasing demands for food quality and safety.

Antimicrobials from Mushrooms for Assuring Food Safety.

Edible mushrooms are rich in anti-inflammatory components, offering therapeutic and health-promoting benefits, making them a valuable constituent of the daily diet for diseases associated with inflammation.

Anti-inflammatory properties of edible mushrooms: A review.

Select edible mushroom species exhibit promising antiplatelet effects, with A. auricularia-judae and P. eryngii showing the highest inhibition rates, while all tested did not alter coagulation parameters.

The Effect of Mushroom Extracts on Human Platelet and Blood Coagulation: In vitro Screening of Eight Edible Species

Medicinal mushrooms exhibit a broad spectrum of health benefits, including antiallergic, antibacterial, antifungal, anti-inflammatory, and antioxidant properties, with potential therapeutic uses in various diseases.

Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials

Medicinal mushrooms show potential in antitumor, immunomodulation, antioxidant, cardioprotective, and antiviral activities, with potential for future drug delivery systems through fungal nanobiotechnology.

Fungal Mushrooms: A Natural Compound With Therapeutic Applications

Mushroom extracts show potential anti-glioma effects by inhibiting cancer cell proliferation, inducing apoptosis, and inhibiting metalloproteinases activity.

Mushrooms as potential therapeutic agents in the treatment of cancer: Evaluation of anti-glioma effects of Coprinus comatus, Cantharellus cibarius, Lycoperdon perlatum and Lactarius deliciosus extracts.

Mushroom extracts can potentially reduce bone loss in the lumbar spine by inhibiting osteoclast activity and promoting osteoblast growth.

Mushroom Extracts Decrease Bone Resorption and Improve Bone Formation.

Edible mushrooms, particularly Shiitake mushrooms, show potential as natural antioxidants due to their high phenolic content and antioxidant activity.

Antioxidant activity and total phenolics of edible mushroom extracts

Shiitake mushroom extracts at 70°C have higher concentrations of savoury-tasting compounds, but less volatile compounds, making them a more effective taste and flavor enhancer for cooked minced meat.

Contributions of non-volatile and volatile compounds to the umami taste and overall flavour of shiitake mushroom extracts and their application as flavour enhancers in cooked minced meat.

These studies suggest that mushroom extracts are generally safe for human use and offer various health benefits, but more well-designed and long-term studies are needed to confirm their efficacy and potential risks.