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These studies suggest that natural supplements such as phytosterols, NCLS, strawberries, nutraceuticals, fiber, plant sterols/stanols, capsaicinoids, ginger, and vitamin C can effectively lower LDL cholesterol levels.
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Plant sterols and stanols are well-documented for their cholesterol-lowering properties. The DESCO study demonstrated that a daily supplement containing 2.5 g of phytosterols significantly reduced total cholesterol (TC) by 11.8 mg/dL and low-density lipoprotein cholesterol (LDL-C) by 7.8 mg/dL in individuals with polygenic hypercholesterolemia. Similarly, a meta-analysis confirmed that plant sterol/stanol supplements can lower LDL-C by approximately 12 mg/dL, showing comparable efficacy to food-based sterol/stanol interventions. These findings suggest that plant sterols and stanols, whether in food or supplement form, are effective in reducing LDL-C levels.
A combined natural cholesterol-lowering supplement (NCLS) containing red yeast rice, policosanols, and artichoke leaf extracts has shown promising results. In a 16-week study, this supplement reduced LDL-C by 14.3% from baseline, along with significant reductions in total cholesterol and apolipoprotein B100. This combination appears to be a potent natural alternative for managing moderate hypercholesterolemia.
Dietary fiber supplements, particularly those containing a mix of water-soluble and non-water-soluble fibers, have been shown to provide significant and sustained reductions in LDL-C. A study involving a fiber supplement composed of guar gum, pectin, soy fiber, pea fiber, and corn bran reported a 12.1% reduction in LDL-C over a 15-week period. This suggests that fiber supplements can be an effective long-term strategy for cholesterol management.
Incorporating antioxidant-rich foods like strawberries into a cholesterol-lowering diet can enhance its effectiveness. A study found that adding strawberries to a diet already rich in soy, viscous fiber, plant sterols, and nuts resulted in a significant reduction in oxidative damage to LDL and maintained reductions in LDL-C and the total to high-density lipoprotein cholesterol ratio. This indicates that antioxidant-rich foods can complement other dietary interventions for better lipid management.
Capsaicinoids, the active components in chili peppers, have also been studied for their cholesterol-lowering effects. A meta-analysis of controlled human trials found that capsaicinoid supplementation significantly reduced serum total cholesterol and LDL-C levels. This suggests that capsaicinoids could be a novel and effective dietary intervention for lowering cholesterol.
Ginger supplementation has been shown to reduce LDL-C and triacylglycerol levels, particularly at doses of 2 grams per day or less. Additionally, vitamin C supplementation at doses of at least 500 mg per day has been found to significantly decrease LDL-C and triglyceride concentrations. These findings highlight the potential of ginger and vitamin C as natural supplements for improving lipid profiles.
Natural supplements such as plant sterols and stanols, combined formulations like NCLS, dietary fibers, antioxidant-rich foods, capsaicinoids, ginger, and vitamin C have all demonstrated efficacy in lowering cholesterol levels. These supplements offer a range of options for individuals seeking natural alternatives to manage their cholesterol and reduce cardiovascular risk. However, it is essential to use these supplements under medical supervision to ensure safety and efficacy.
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