The current arsenal of antibiotics, including 'old antibiotics', is sufficient to combat new bacterial resistance and should be considered a World Heritage.

Do we need new antibiotics?

Antibiotic use in hospital settings should be tailored to the infection, risk factors, and local microbiology, with optimal dosing and duration, and a focus on infection control.

Ten key points for the appropriate use of antibiotics in hospitalised patients: a consensus from the Antimicrobial Stewardship and Resistance Working Groups of the International Society of Chemotherapy.

New antibiotics are urgently needed to combat antibiotic resistance, as infections become increasingly untreatable due to resistance emerging and spreading at new sites.

The need for new antibiotics.

Limit antibiotic treatment duration to 5 days for COPD exacerbations, community-acquired pneumonia, UTIs, and cellulitis, based on clinical stability.

Appropriate Use of Short-Course Antibiotics in Common Infections: Best Practice Advice From the American College of Physicians

The guideline outlines strategies for enhancing rational use of antibiotics in hospitals, counteracting antimicrobial resistance, and improving patient care by maximizing clinical outcomes and minimizing toxicity.

Strategies to enhance rational use of antibiotics in hospital: a guideline by the German Society for Infectious Diseases

New antibacterial agents are crucial for combating resistant Gram-negative bacteria, with promising strategies including deactivating resistance mechanisms and developing naturally derived agents on novel targets.

Resistance of Gram-Negative Bacteria to Current Antibacterial Agents and Approaches to Resolve It

Hospital-wide antibiotic stewardship programs and adapting clinical guidelines can effectively reduce antibiotic resistance, while vaccines and nonimmunogenic treatment options may also be effective.

Appropriate use of antibiotics: an unmet need

New antibiotics are needed to combat antibiotic resistance and address the growing health needs caused by emerging and opportunistic pathogens.

Discovery and development of new antibiotics: the problem of antibiotic resistance

Darobactin, a new antibiotic found in Photorhabdus symbionts of nematode microbiomes, shows potential for developing into therapeutics against drug-resistant Gram-negative pathogens.

A new antibiotic selectively kills Gram-negative pathogens

Nonmedical uses of antibiotics, such as in animal husbandry and horticulture, should be critically examined and halted to prevent the spread of antibiotic-resistant bacteria.

Nonmedical Uses of Antibiotics: Time to Restrict Their Use?

Alternative drug targets and therapies, such as combinational therapy, anti-regulator, anti-signal transduction, anti-virulence, anti-toxin, engineered bacteriophages, and microbiome, are crucial for overcoming antibiotic-resistant bacteria in a post-antibiotic era.

Defeating Antibiotic-Resistant Bacteria: Exploring Alternative Therapies for a Post-Antibiotic Era

Antibiotic resistance in the food chain requires comprehensive policymakers and alternative therapeutics to combat the threat to public health.

Antibiotics in Food Chain: The Consequences for Antibiotic Resistance

Antibiotic resistance is a global crisis, affecting medical science and necessitating multidisciplinary efforts to study emerging microorganisms and develop alternative therapies.

Antibiotic resistance: a rundown of a global crisis

Probiotics show potential in preventing Clostridium difficile-associated diarrhea in adults and children, but more research is needed to confirm their effectiveness and safety.

Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children.

Alternatives to antibiotics, such as antibodies, probiotics, and vaccines, show promise as adjunctive or preventive therapies, but require more than £15 billion in funding over 10 years for validation in phase 2 trials.

Alternatives to antibiotics-a pipeline portfolio review.

Antibiotics face challenges from antimicrobial resistance and cost-effectiveness, but innovations in discovery hold promise for the future.

The past, present, and future of antibiotics

Non-antibiotic treatments are crucial for managing bacterial infections in the face of increasing antibiotic resistance, as they offer a promising alternative to traditional antibiotics for many infections.

Non-antibiotic treatments for bacterial diseases in an era of progressive antibiotic resistance

Antibiotic resistance is a growing threat, and strategies like control programs, better hygiene, and synthesis of improved antimicrobial agents are needed to limit its spread.

The Crisis in Antibiotic Resistance

Understanding antibiotic resistance evolution and spread is crucial for developing effective treatment strategies to combat the global health and economic burden of antibiotic resistance.

The evolution of antibiotic resistance

Soil bacteria can thrive on antibiotics as a sole carbon source, contributing to the increasing levels of multiple antibiotic resistance in pathogenic bacteria.

Bacteria Subsisting on Antibiotics

Some studies suggest that the current arsenal of antibiotics is sufficient and should be used judiciously, while other studies emphasize the urgent need for new antibiotics to combat increasing resistance and emerging pathogens.