New indicator for stroke
Pro Research Analysisby 
Searched over 200M research papers
Consensus Meter
New Indicators for Stroke: A Comprehensive Overview
Blood Biomarkers for Stroke Diagnosis and Prognosis
C-Reactive Protein, P-Selectin, and Homocysteine
Recent research has identified several blood biomarkers that can differentiate between ischemic stroke and healthy individuals. Notably, C-reactive protein, P-selectin, and homocysteine have shown significant potential in this regard.
Glial Fibrillary Acidic Protein and Glucose Levels
For distinguishing between hemorrhagic and ischemic strokes, glial fibrillary acidic protein levels are significant. Additionally, high admission glucose levels are strong predictors of poor prognosis following ischemic stroke and symptomatic intracerebral hemorrhage post-thrombolysis.
Glutamate, D-Dimer, and Fibrinogen
Glutamate levels indicate progressive stroke, while D-dimer levels predict in-hospital death. High fibrinogen levels are associated with poor outcomes at three months post-ischemic stroke.
Arteriosclerotic Indicators in Ischemic Stroke
Ankle-Brachial Index (ABI), Brachial-Ankle Pulse Wave Velocity (baPWV), and Cardio-Ankle Vascular Index (CAVI)
The ABI, baPWV, and CAVI are surrogate markers of arteriosclerosis. In patients with acute ischemic stroke, a lower ABI indicates advanced atherosclerosis associated with large-artery atherosclerosis (LAA). Increased baPWV and CAVI are more closely associated with acute ischemic stroke (AIS).
Cerebral Oxygen and Blood Pressure Coupling
Coupling Strength as a Stroke Risk Predictor
A novel approach involves evaluating the coupling strength between cerebral oxygen and blood pressure signals. This coupling strength, calculated using wavelet analysis and dynamic Bayesian inference, serves as a quantitative index of cerebral blood flow autoregulation. Higher coupling strength is significantly associated with higher stroke risk, making it a valuable predictor for stroke prevention and intervention.
Turbulence Intensity in Carotid Web
Turbulence Intensity (TI) as an Indicator
In cases of carotid web (CaW), turbulence intensity (TI) has been identified as a potential indicator for ischemic stroke. High TI, especially in conditions of high stenosis rate and small angle, correlates with increased stroke risk. This finding suggests that TI could be used in clinical settings to assess stroke risk in CaW patients.
Echocardiographic Indicators for Cardioembolic Stroke
Diastolic Dysfunction and E/A Ratio
New echocardiographic indicators, such as the mitral ratio of peak early to late diastolic filling velocity (E/A), have shown significant predictive value for cardioembolic (CE) stroke. An E/A ratio greater than 2.0 is a strong predictor of CE stroke, particularly in female patients.
Passive Surveillance Stroke Severity Indicator
Administrative Data for Stroke Severity
A passive surveillance stroke severity indicator has been derived from routinely collected administrative data. This indicator, based on variables such as age, sex, and emergency department triage scores, provides a reliable measure of stroke severity and can be used for risk adjustment in population-based stroke outcomes research.
miRNA-Based Diagnostic Indicator
miR-4420 and miR-6793-5p
A panel of two miRNAs, miR-4420 and miR-6793-5p, correlated with systolic blood pressure, has been developed as a diagnostic indicator for stroke. This panel has shown high diagnostic accuracy and could be a valuable tool for early stroke detection.
Neutrophil-to-Lymphocyte Ratio (NLR)
Inflammatory Indicator for Stroke
The neutrophil-to-lymphocyte ratio (NLR) is an important inflammatory indicator that correlates with stroke outcomes. Higher NLR levels are associated with increased risk of ischemic stroke, unfavorable functional outcomes, and increased mortality in both ischemic and hemorrhagic strokes.
Transcranial Doppler Signals for Stroke Rehabilitation
External Counterpulsation (ECP) Treatment
A new index derived from transcranial Doppler (TCD) signals has been developed to evaluate the effects of long-term external counterpulsation (ECP) treatment on stroke rehabilitation. This index, which measures significant fluctuations in TCD signals, correlates with improvements in stroke severity and functional outcomes.
Conclusion
The identification of new indicators for stroke, ranging from blood biomarkers to advanced imaging techniques, offers promising avenues for early diagnosis, risk prediction, and effective treatment. These indicators not only enhance our understanding of stroke pathophysiology but also pave the way for personalized medicine and improved patient outcomes.
Sources and full results
Most relevant research papers on this topic