Noni juice dosage and health effects
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Noni Juice Dosage in Research Studies
Several studies have explored the dosage of noni juice (Morinda citrifolia) for health effects in both animal and human models. In animal studies, dosages commonly ranged from 2 mL/kg to 4.55 mL/kg per day, administered orally or intraperitoneally for periods ranging from 5 days to 60 days 1246. In human studies, a typical dosage was 4 fluid ounces (about 120 mL) per day, consumed over 90 days . Another human study used 150 mL per day for 10 days in diabetic patients .
Health Effects of Noni Juice
Blood Glucose and Diabetes Management
Noni juice has shown potential in lowering blood glucose levels. In diabetic rats, chronic supplementation (2 mL/kg daily for 60 days) improved glycemic control and physical performance . In a human study, diabetic patients who consumed 150 mL of noni juice daily for 10 days experienced a significant reduction in blood glucose compared to controls . These effects are attributed to the juice’s flavonoid content and antioxidant properties 19.
Antioxidant and Anti-Inflammatory Properties
Noni juice is rich in antioxidants, which help reduce oxidative stress and inflammation. Studies have demonstrated that noni juice increases antioxidant activity in human plasma and red blood cells, with effects stronger than those of orange juice . Animal studies also confirm its antioxidant and anti-inflammatory effects, including reduced lung inflammation and protection against acute kidney and liver toxicity 2346710.
Immune Modulation
Research in mice indicates that noni juice can modulate immune responses, increasing or decreasing certain cytokines depending on the dosage and organ involved. While some immune markers increased at higher concentrations, no significant disturbances in liver or kidney function were observed outside of immune modulation .
Perceived Health Benefits in Humans
A 90-day in-home use test with 319 adults found that 94% reported some improvement in health after daily consumption of 4 ounces of noni juice. Over 80% felt generally healthier, and more than 70% believed noni juice was more effective than other wellness supplements they had tried .
Organ Protection and Toxicity
Noni juice has demonstrated protective effects against acute liver and kidney injury in animal models, reducing tissue damage and oxidative stress 34. However, chronic high-dose supplementation in diabetic rats caused signs of kidney toxicity, such as increased Bowman's space area, suggesting potential risks with long-term or high-dose use .
Safety and Side Effects
While noni juice is generally considered safe at moderate doses, some studies have reported potential kidney toxicity with chronic high-dose use in animals . Short-term use did not cause significant organ disturbances in animal models, but mild intestinal edema was observed at the highest concentrations . Human studies have not reported serious adverse effects at typical consumption levels 59.
Conclusion
Noni juice, at dosages ranging from 2 mL/kg in animals to 120–150 mL per day in humans, has demonstrated benefits for blood glucose control, antioxidant activity, immune modulation, and perceived general health. However, caution is advised with long-term or high-dose use due to potential kidney toxicity observed in animal studies. Moderate daily consumption appears to be safe and may offer health benefits, but further research is needed to confirm long-term safety and efficacy in humans.
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