Norvasc maximum dose
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Maximum Dose of Norvasc (Amlodipine Besylate)
Introduction to Norvasc (Amlodipine Besylate)
Norvasc, known generically as amlodipine besylate, is a calcium channel blocker used primarily to treat high blood pressure and angina. It works by relaxing blood vessels, allowing blood to flow more easily, and reducing the workload on the heart.
Recommended Dosage and Maximum Dose
The typical dosage of Norvasc for adults ranges from 5 mg to 10 mg per day. Clinical trials have demonstrated that doses up to 10 mg daily are generally well-tolerated and effective in managing hypertension and angina .
Safety and Efficacy at Maximum Dose
Studies have shown that Norvasc at a dose of 10 mg per day is effective in reducing blood pressure and managing symptoms of chronic conditions such as heart failure and chronic renal insufficiency . In a comparative study, patients with chronic renal insufficiency and hypertension who were administered Norvasc at doses up to 10 mg daily showed significant reductions in both systolic and diastolic blood pressure without significant adverse effects.
Side Effects and Adverse Reactions
While Norvasc is generally well-tolerated, some side effects are dose-related. Common side effects at higher doses (10 mg) include edema, dizziness, flushing, and palpitations. In clinical trials, the incidence of edema was notably higher at the 10 mg dose compared to lower doses. However, the overall discontinuation rate due to adverse reactions was low, indicating that most patients can tolerate the maximum dose with manageable side effects.
Special Considerations
Patients with severe hepatic impairment should be administered Norvasc with caution, as the drug is extensively metabolized by the liver, and its plasma elimination half-life is significantly prolonged in these patients. Additionally, while Norvasc has been shown to be safe in patients with various comorbid conditions, including chronic obstructive pulmonary disease and diabetes mellitus, it is essential to monitor for potential interactions with other medications.
Conclusion
The maximum recommended dose of Norvasc is 10 mg per day. This dosage has been proven effective and generally well-tolerated in clinical studies, although patients should be monitored for dose-related side effects. Special caution is advised for patients with severe hepatic impairment. Overall, Norvasc remains a reliable option for managing hypertension and angina at its maximum dose.
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