Norvasc side effects
Pro Research Analysisby 
Searched over 200M research papers
Side Effects of Norvasc (Amlodipine)
Common Side Effects of Norvasc
Edema and Swelling
One of the most frequently reported side effects of Norvasc (amlodipine) is edema, particularly in the lower extremities. Studies have shown that leg edema occurs in approximately 10.5% of patients taking amlodipine for hypertension. Additionally, a case report highlighted a patient who developed bipedal pitting edema after starting amlodipine, which resolved after discontinuation of the drug.
Headaches and Dizziness
Headaches are another common side effect, affecting around 2% of patients. Dizziness has also been reported, although it appears to be less common. These side effects are generally mild and transient, resolving without the need for medical intervention.
Less Common but Notable Side Effects
Gingival Hyperplasia and Telangiectasia
A rare but notable side effect is gingival hyperplasia, which is the overgrowth of gum tissue. This was observed in a 3-year-old patient who also developed telangiectasia (small dilated blood vessels) on the cheeks. These side effects are unusual and may lead to a delay in diagnosis due to their rarity.
Conjunctival Chemosis
Another rare side effect is conjunctival chemosis, which is swelling of the conjunctiva (the membrane covering the white part of the eye). This was reported in a 69-year-old patient who also experienced bipedal edema. The chemosis resolved six months after stopping amlodipine.
Comparative Safety with Other Antihypertensives
Chronic Renal Insufficiency
In patients with chronic renal insufficiency, Norvasc has been found to be as effective and safe as other antihypertensive medications like Yashida. Both drugs significantly lowered systolic and diastolic blood pressure without significant differences in side effects.
Long-term Safety
Long-term studies, such as the Prospective Randomized Evaluation of the Vascular Effects of Norvasc (PREVENT) trial, have shown that amlodipine does not increase the risk of major cardiovascular events or cancer. However, the trial did not find a significant effect on the progression of coronary atherosclerosis .
Conclusion
Norvasc (amlodipine) is generally well-tolerated and effective for treating hypertension, but it can cause side effects such as edema, headaches, and, less commonly, gingival hyperplasia and conjunctival chemosis. While these side effects are usually mild and transient, they can occasionally be severe enough to warrant discontinuation of the drug. Overall, Norvasc remains a reliable option for managing hypertension, with a safety profile comparable to other antihypertensive medications.
Sources and full results
Most relevant research papers on this topic