The revised International Association for the Study of Pain definition of pain is "An unpleasant sensory and emotional experience associated with, or resembling, actual or potential tissue damage."

The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises.

The neuromatrix theory proposes that pain is produced by a brain network, rather than directly by sensory input, and is influenced by multiple factors, including somatic sensory input.

Pain: an overview

Pain is a specific modality with its own central and peripheral apparatus, and its nerve impulse pattern is produced by intense stimulation of nonspecific receptors, contrasting with the pattern theory.

Pain mechanisms: a new theory.

Pain is a significant clinical, social, and economic issue, with varying prevalence and incidence estimates, but the burden is unquestionably large.

The epidemiology and economic consequences of pain.

Pain is a complex sensation influenced by various factors, including the specificity of pain, its neural mechanisms, and the relationship between pain and other emotions.

Ideas about pain, a historical view

The neuromatrix theory proposes that pain is produced by neurosignature patterns generated by a wide distributed neural network in the brain, rather than directly by sensory input evoked by injury, inflammation, or other pathology.

Pain – an overview

Pain modulation is influenced by psychological, social, and contextual factors, with pain experiences sometimes acting as a form of reward in certain contexts.

Pain and the context

Neuronal mechanisms play a crucial role in the pathophysiology of nociceptive pain from inflammation and injury, and neuropathic pain from nerve damage, affecting various clinical pain states.

Pathophysiology of pain

Chronic pain and suffering are caused by an imbalance between ascending and descending pain inhibitory pathways, with potential therapeutic treatments aiming to rebalance these pathways.

The anatomy of pain and suffering in the brain and its clinical implications

Chronic pain contributes to suffering by promoting a destructive stress response, leading to negative thinking and impairing mental and physical performance, and physicians can help by controlling pain.

Suffering: the contributions of persistent pain

Neuronal oscillations at different frequencies in the brain contribute to the experience of pain, potentially impacting our understanding and treatment of chronic pain.

Brain Rhythms of Pain

A pain is a subjective experience in a body part, but it is also an emotional experience, and this paper proposes a qualia-friendly, naturalistic, and weakly intentionalist account of pain-attributing judgments.

What Is a Pain in a Body Part?

Pain can be adaptive or maladaptive, and targeting underlying causes could revolutionize pain diagnosis and management.

Can we conquer pain?

Pain is a complex sensation, but understanding its genes, molecules, cells, and circuits offers new opportunities for managing it.

What is this thing called pain?

Pain is more than just the result of specific injury, with cognitive, motivational, and psychological factors playing a significant role in determining the pain experience.

The relation of injury to pain

Pain management is crucial for cancer patients, as it is a subjective and emotional experience, and fear of pain is a major factor in their attitudes towards cancer treatment.

THE ACUTE ABDOMEN

Chronic pain is common in childhood and adolescence, with higher prevalence in girls aged 12 and over, and higher intensity in both chronic and multiple pain types.

Pain in children and adolescents: a common experience

Depression and pain are closely related and often occur together, requiring simultaneous assessment and treatment for improved outcomes.

Depression and pain.

Shared pain experiences can promote trusting interpersonal relationships and increased cooperation within social groups.

Pain as Social Glue

Pain is a significant factor in problem behavior in cats and dogs, with a prevalence of 28-82%, and veterinarians should treat suspected pain first rather than considering its significance only after behavior therapy fails.

Pain and Problem Behavior in Cats and Dogs

These studies suggest that pain is a complex sensory and emotional experience influenced by neural mechanisms, psychological and social factors, and can be modulated by various pathways and contexts.