How does PI3K contribute to cell movement?

Introduction

Phosphoinositide 3-kinases (PI3Ks) are a family of enzymes involved in various cellular processes, including cell growth, survival, proliferation, and movement. The role of PI3K in cell movement is particularly significant, as it influences cytoskeletal rearrangements and membrane dynamics essential for cell migration. This synthesis aims to consolidate findings from multiple research papers to elucidate how PI3K contributes to cell movement.

Key Insights

PI3K Activation and Cytoskeletal Rearrangements:
- PI3K activation leads to the production of phospholipids like PtdIns(3,4,5)P3, which bind to specific PH domains in proteins, regulating cytoskeletal and membrane rearrangements necessary for cell movement .
Role of Small GTPases:
- PI3K activity is linked to the activation of small GTPases from the Rho and Arf families, which are crucial for cytoskeletal dynamics and cell motility .
PKB/Akt Pathway:
- The PI3K/Akt pathway is directly involved in promoting cell motility. Hyperactivation of this pathway can enhance cell migration and invasion, particularly in cancer cells .
Excitable Signaling Networks:
- The Ras/PI3K/ERK signaling network exhibits excitable properties that drive actin-based protrusions, facilitating cell migration. This network's activity is heightened in oncogenic transformations, increasing cell motility.
Immune Cell Migration:
- In immune cells, PI3K signaling regulates migration by coordinating responses to various stimuli, including antigens and cytokines. Specific PI3K isoforms play distinct roles in these processes .

Conclusion

PI3K contributes to cell movement through several mechanisms, including the production of signaling lipids that regulate cytoskeletal rearrangements, activation of small GTPases, and engagement of the PI3K/Akt pathway. These processes are crucial for normal cellular functions and are often dysregulated in cancer, leading to increased cell motility and metastasis. Understanding these pathways provides insights into potential therapeutic targets for diseases involving aberrant cell migration.

How does PI3K contribute to cell movement?

Summary

Introduction

Key Insights

Conclusion

Sources and full results

Signalling through Class I PI3Ks in mammalian cells.

The Class I PI3K signaling pathway plays a crucial role in regulating cell growth, survival, proliferation, and movement, making it a promising target for developing novel therapeutics.

PI3K in lymphocyte development, differentiation and activation

PI3Ks play a crucial role in lymphocyte development, differentiation, and activation, with their subunits p110 playing a key role in antigen-receptor signaling in B and T cells.

PI3K signaling controls cell fate at many points in B lymphocyte development and activation.

PI3K signaling plays a critical role in B lymphocyte development, proliferation, and differentiation, with various stimulatory and inhibitory receptors influencing its activity.

An Excitable Ras/PI3K/ERK Signaling Network Controls Migration and Oncogenic Transformation in Epithelial Cells.

The Ras/PI3K/ERK signaling network plays a crucial role in epithelial cell migration and oncogenic transformation, with oncogenic transformation causing a shift to a lower threshold, potentially aiding in cancer assessment and intervention effectiveness.

The role of PI3K in immune cells

PI3K plays a crucial role in immune cell growth, survival, and cytoskeletal remodeling, with gene-targeted mice enabling in vivo examination of individual enzymes' physiological functions in the immune system.

PKB/Akt-dependent regulation of cell motility.

The PI3K/Akt pathway plays a crucial role in cell motility, influencing cell migration, invasion, and cancer metastasis.

The PI3K Pathway in Human Disease

PI3Ks play crucial roles in cellular metabolism and immune system functions, impacting oncology and influencing the efficacy and toxicity of PI3K-targeted therapies.

Emergence of the PI3-kinase pathway as a central modulator of normal and aberrant B cell differentiation.

The PI3-kinase pathway plays a central role in normal and aberrant B cell differentiation, with new insights into its regulation potentially impacting new treatments for B cell malignancies and autoimmune diseases.

Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions.

Drosophila's insulin/PI3-kinase pathway plays a crucial role in coordinating cellular metabolism with nutritional conditions, preventing starvation sensitivity and affecting cell growth.

PIK3CA Gene

PI3K signaling plays a crucial role in cell growth, division, and survival, as well as hormone regulation and fat cell maturation.

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