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Single-Pill Combinations (SPCs) and Medication Adherence
Improved Medication Adherence with Single-Pill Combinations
Single-pill combinations (SPCs) of antihypertensive medications have been shown to significantly improve medication adherence compared to multiple-pill combinations (MPCs). A nationwide study in Korea demonstrated that the medication possession ratio (MPR), an indirect measure of adherence, was higher for SPCs (89.7%) compared to MPCs (87.2%) and monotherapies (81.6% for ARB and 79.7% for CCB)1. This trend was more pronounced in older adults and those taking a higher number of medications, indicating that SPCs can simplify treatment regimens and enhance adherence, particularly in complex cases1.
Clinical Outcomes and Mortality Reduction with SPCs
In addition to improving adherence, SPCs have been associated with better clinical outcomes and reduced all-cause mortality in patients with cardiovascular diseases. A study analyzing data from a German sickness fund found that patients treated with SPCs had significantly lower incidence rates of cardiovascular events such as stroke, myocardial infarction, and heart failure compared to those on MPCs2. The study also reported lower all-cause hospitalization and mortality rates for the SPC group, suggesting that the simplified regimen not only improves adherence but also enhances overall patient prognosis2.
Missed Period Pills (MPP) and Reproductive Health
Interest in Missed Period Pills
Missed period pills (MPP), which are used for uterine evacuation in cases of delayed menses without prior pregnancy confirmation, have garnered significant interest among individuals seeking pregnancy test services. A study conducted in two US states found that 42% of participants expressed interest in MPPs, with the highest interest among those who would be unhappy if pregnant (70%)3. Factors associated with higher interest included being over 35 years old, nulliparity, prior abortion, contraceptive use, and recent use of emergency contraception3.
Reasons for Interest and Disinterest
The primary reasons for interest in MPPs included the desire to prevent or terminate a pregnancy and the psychological benefits of managing abortion stigma3. Conversely, concerns about safety, side effects, and a desire to maintain a pregnancy were the main reasons for disinterest3. These findings suggest that MPPs could meet a substantial and diverse demand, potentially expanding reproductive service options and improving patient-centered care in the United States3.
Conclusion
The use of single-pill combinations (SPCs) in antihypertensive and cardiovascular treatments significantly improves medication adherence and clinical outcomes, including reduced all-cause mortality. Additionally, there is notable interest in missed period pills (MPP) for managing delayed menses, indicating a potential expansion in reproductive health services. Both SPCs and MPPs represent advancements in simplifying treatment regimens and enhancing patient care.
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Most relevant research papers on this topic
Effects of combination drugs on antihypertensive medication adherence in a real-world setting: a Korean Nationwide Study
Single-pill combinations (SPCs) of antihypertensive drugs show higher adherence than multiple-pill combinations (MPCs), with a more pronounced effect as age and medication number increase.
Observational Study
Rigorous JournalSingle pill treatment in daily practice is associated with improved clinical outcomes and all-cause mortality in cardiovascular diseases: results from the START project
Single pill treatments (SPC) are clinically superior to multi pill combinations (MPC) in reducing cardiovascular events and all-cause mortality in daily practice.
Rigorous JournalExploring potential interest in missed period pills in two US states.
Missed period pills have substantial interest in the US, particularly among those who would be unhappy if pregnant and those with prior abortions and contraceptive use.
Observational StudyAdherence to single-pill combination versus multiple-pill combination lipid-modifying therapy among patients with mixed dyslipidemia in a managed care population
Single-pill combination lipid-modifying therapies show significantly higher adherence than multi-pill combination therapies in patients with mixed dyslipidemia.
Observational StudyEffects of Single Pill Combinations Compared to Identical Multi Pill Therapy on Outcomes in Hypertension, Dyslipidemia and Secondary Cardiovascular Prevention: The START-Study
Single pill combinations (SPC) are associated with a lower incidence of cardiovascular events and lower all-cause mortality, making them a preferred treatment option for patients with hypertension, dyslipidemia, and secondary cardiovascular prevention.
Observational Study
Very Rigorous JournalFunctional ovarian cysts in users of combined oral contraceptives versus medroxyprogesteroneacetate (M.P.A)
Combined oral contraceptive pills have a lower risk of follicular cyst formation than medroxyprogesterone acetate injection.
Serum phosphorus levels and pill burden are inversely associated with adherence in patients on hemodialysis
Higher adherence to phosphate binders in hemodialysis patients is associated with lower phosphorus levels and better phosphorus target achievement.
Observational Study
Highly CitedOral contraceptive tablets containing 20 and 30 μg of ethinyl estradiol with 150 μg desogestrel: Their influence on lipids, lipoproteins, sex hormone binding globulin and testosterone
Both oral contraceptives with 20 and 30 g of ethinyl estradiol show beneficial changes in plasma lipids and lipoproteins, but the clinical significance of these differences remains uncertain.
RCTMulti-Stage Heavy Pill Displacement Using Managed Pressure Tripping Technique in High Pressure-High Temperature Well with Narrow Drilling Margin - A Case Study in Haynesville Shale
Automated Managed Pressure Tripping techniques effectively control bottom-hole pressure in HPHT formations, improving operational efficiency, cost, and safety in Haynesville shale gas wells.
Impact of medication packaging on adherence and treatment outcomes in older ambulatory patients.
Daily-dose blister packaging (Pill Calendar) improves medication adherence and treatment outcomes in elderly patients compared to traditional bottles of loose tablets.
RCTHighly Cited