does resistant exercise affect irisin

Introduction

Irisin is a myokine released during physical exercise, which has been proposed to play a role in energy metabolism, insulin sensitivity, and body composition. This synthesis aims to evaluate the effects of resistance exercise on circulating irisin levels based on findings from multiple research studies.

Key Insights

Resistance Exercise Increases Irisin Levels:
- Resistance exercise leads to a significant increase in plasma irisin levels compared to endurance exercise and combined exercise modes .
- Chronic resistance training programs, especially those that are demanding and progressive, tend to increase circulating irisin levels, particularly in older adults .
Irisin and Body Composition:
- Resistance training-induced increases in irisin levels are associated with reductions in body fat percentage and increases in muscle mass .
- There is a positive correlation between changes in circulating irisin and muscle mass, and a negative correlation with fat mass.
Irisin and Metabolic Health:
- Irisin may play a role in improving insulin sensitivity and reducing insulin resistance, which are beneficial for metabolic health .
- However, some studies suggest that the increase in resting metabolic rate (RMR) due to resistance training is not mediated by changes in irisin levels.
Inconsistent Findings:
- Some studies report no significant changes in circulating irisin levels following resistance exercise, indicating variability in responses based on different study designs and populations .

Conclusion

Resistance exercise generally leads to an increase in circulating irisin levels, particularly in older adults and when the training is progressive and demanding. This increase is associated with beneficial changes in body composition, such as reduced body fat and increased muscle mass. While irisin may contribute to improved insulin sensitivity, its role in mediating changes in resting metabolic rate remains unclear. Variability in findings suggests that more research is needed to fully understand the relationship between resistance exercise and irisin.

Does resistant exercise affect irisin

Summary

Consensus Meter

Introduction

Key Insights

Conclusion

Sources and full results

Resistance exercise induces a greater irisin response than endurance exercise.

Resistance exercise induces greater irisin responses than endurance exercise alone and resistance and endurance exercises combined.

Effect of Chronic Resistance Training on Circulating Irisin: Systematic Review and Meta-Analysis of Randomized Controlled Trials

Chronic resistance training programs may increase circulating irisin, particularly in older adults and demanding and progressive training programs.

Effects of 12 Weeks Resistance Training on Serum Irisin in Older Male Adults

Resistance training for 12 weeks significantly increases serum irisin levels in older male adults, potentially regulating body fat levels.

Irisin does not mediate resistance training-induced alterations in resting metabolic rate.

Preventive resistance training increases resting metabolic rate without affecting fat-free mass or irisin concentration, casting doubt on the role of irisin in human energy balance.

Molecular Basis of Irisin Regulating the Effects of Exercise on Insulin Resistance

Irisin, a novel myokine, regulates the effects of exercise on insulin resistance by promoting glucose uptake, improving mitochondrial function, alleviating obesity, and decreasing inflammation.

Effect of aerobic training and resistance training on circulating irisin level and their association with change of body composition in overweight/obese adults: a pilot study.

Resistance training effectively increases circulating irisin levels and positively impacts body composition in overweight/obese adults, suggesting it as an efficient exercise type.

Can Resistance Exercise Alter Irisin Levels and Expression Profiles of FNDC5 and UCP1 in Rats?

Resistance exercise may improve body composition by increasing thermogenesis in white adipose tissue through the secretion of irisin.

ACUTE EFFECT OF BLOOD FLOW RESTRICTED RESISTANCE EXERCISE ON IRISIN AND SEX HORMONES

Acute changes in irisin and sex hormone levels were not statistically different between low-intensity blood flow restricted resistance exercise and high-intensity non-BFR exercise.

Chronic Exercise Training and Circulating Irisin in Adults: A Meta-Analysis

Chronic exercise training leads to significantly decreased circulating irisin levels in randomized controlled trials, but evidence remains inconclusive in non-randomized studies.

The effects of aerobic, resistance, and combined exercises on the plasma irisin levels, HOMA-IR, and lipid profiles in women with metabolic syndrome: A randomized controlled trial

A systematic exercise program for 8 weeks did not change circulating irisin, but serum irisin is independently associated with glycemic status, body fat, and weight in overweight women with metabolic syndrome.

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