SARMs show potential for safe use in treating cancer-related cachexia, benign prostatic hyperplasia, hypogonadism, breast cancer, and prostate cancer.

Selective Androgen Receptor Modulators: Current Knowledge and Clinical Applications.

GSK2881078 shows pharmacodynamic effects with acceptable tolerability and supports further clinical evaluation for its potential use in muscle building and weight loss.

Safety, pharmacokinetics and pharmacological effects of the selective androgen receptor modulator, GSK2881078, in healthy men and postmenopausal women

SARMs can increase lean body mass in athletes, but their safety and potential contamination remain unclear.

Poster 390: Systematic Review of SARMs Abuse in Athletes

Recreational SARM use is strongly discouraged due to the risks of drug-induced liver injury, rhabdomyolysis, and tendon rupture.

Systematic Review of Safety of Selective Androgen Receptor Modulators in Healthy Adults: Implications for Recreational Users

SARM supplements marketed online often contain inaccurate claims and discrepancies, posing a high risk to consumers due to uncertainty over dose and drug identity.

Analysis of supplements available to UK consumers purporting to contain Selective Androgen Receptor Modulators.

SARMs show promise in preclinical investigations and initial clinical trials, but long-term safety, tolerability, and efficacy studies are needed for their widespread clinical use.

Deciphering the selective androgen receptor modulators paradigm

SARMs show promise in developing tissue-selective androgen therapies with improved efficacy and safety, potentially transforming androgen therapy for various male and female disorders.

Selective androgen receptor modulators (SARMs): a novel approach to androgen therapy for the new millennium.

SARMs may not be a safer alternative to anabolic androgenic steroids due to potential contraindications and deleterious effects, and their use across various demographics remains controversial.

Considerations, possible contraindications, and potential mechanisms for deleterious effect in recreational and athletic use of selective androgen receptor modulators (SARMs) in lieu of anabolic androgenic steroids: A narrative review

Investing in basic research could accelerate the discovery of more selective and safer SARMs, potentially treating an expanded range of clinical conditions.

Improving selective androgen receptor modulator discovery and preclinical evaluation

Social media misinformation may lead individuals to believe SARMs are safe, and healthcare providers and sports team members should educate themselves on the drug to prevent abuse.

Social media’s impact on widespread SARMs abuse

SARMs are used for various indications, including osteoporosis, anemia, male contraception, male hypogonadism, and wound healing, without causing prostate hypertrophy, secondary sex characteristics, or accelerating prostate cancer development.

Selective Androgen Receptor Modulators as Function Promoting Therapies.

SARMs show potential as viable alternatives to current androgen therapies for various conditions, with few side effects and excellent oral and transdermal bioavailability.

Selective androgen receptor modulators: the future of androgen therapy?

SARMs show potential as therapeutic agents for various diseases by maximizing positive attributes of steroidal androgens while minimizing negative effects, offering potential in muscle wasting associated with burns, cancer, end-stage renal disease, osteoporosis, frailty, and hypogonadism.

Therapeutic potential of the SARMs: revisiting the androgen receptor for drug discovery

SARMs, which dissociate anabolic and androgenic activities of the androgen receptor for therapeutic benefit.

Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit.

SARMs offer a promising treatment for various diseases by selectively activating androgen receptors in target tissues, with reduced side-effects.

Development of selective androgen receptor modulators (SARMs)

SARMs show potential in extending androgen therapy for osteoporosis, muscle wasting, male contraception, and prostate diseases due to their improved pharmacokinetic characteristics and tissue-selective pharmacological activities.

Expanding the therapeutic use of androgens via selective androgen receptor modulators (SARMs).

SARMs show promise as a new class of function-promoting anabolic therapies for aging, chronic disease, frailty, cancer cachexia, and osteoporosis without adversely affecting prostate and cardiovascular outcomes.

Selective androgen receptor modulators as function promoting therapies

NanoMIP-based sensors can detect SARMs in serum at low to sub nM levels, below the minimum required performance limit set by WADA.

Detection of selective androgen receptor modulators (SARMs) in serum using a molecularly imprinted nanoparticle surface plasmon resonance sensor.

SARMs show potential as novel targeted therapies for treating AR-positive triple-negative breast cancer by inhibiting tumor growth and metastasis-promoting paracrine factors.

Selective Androgen Receptor Modulators (SARMs) Negatively Regulate Triple-Negative Breast Cancer Growth and Epithelial:Mesenchymal Stem Cell Signaling

This study successfully synthesized two major equine arylpropionamide-based SARM metabolites, which can now be used as reference standards for routine mass spectrometry-based doping control analysis of performance-enhancing drugs.

Structural elucidation of major selective androgen receptor modulator (SARM) metabolites for doping control.

Is SARMs (Selective Androgen Receptor Modulators) safe?

Some studies suggest SARMs show potential for safe use in specific medical conditions and muscle building, while other studies highlight significant risks such as liver injury, rhabdomyolysis, tendon rupture, and the need for more research on long-term safety.