Is SARMs (Selective Androgen Receptor Modulators) safe?

Introduction

Selective Androgen Receptor Modulators (SARMs) are a class of compounds that selectively target androgen receptors to produce anabolic effects, such as muscle growth, while aiming to minimize the side effects typically associated with anabolic steroids. They are under investigation for various clinical applications, including muscle wasting diseases, osteoporosis, and certain cancers.

Key Insights from Research Papers

SARMs have shown potential in clinical studies for treating conditions like cachexia, benign prostatic hyperplasia, hypogonadism, and breast cancer, with a good safety profile and minimal drug interactions .
Unlike traditional anabolic steroids, SARMs offer the possibility of muscle and bone growth with reduced impact on the prostate, suggesting a favorable therapeutic profile .
Concerns about the safety of SARMs arise from their use in recreational and athletic contexts, where high doses and potential contamination from online sources could pose health risks, including drug-induced liver injury and tendon rupture .
SARMs are not approved by the U.S. Food and Drug Administration (FDA), and their long-term safety profile is not fully understood, warranting caution and further research .
Despite the lack of FDA approval, SARMs are being used off-label, and their easy availability online has led to misuse in sports and recreational bodybuilding, with potential side effects that are not yet fully characterized .

Conclusion

SARMs present a promising avenue for the treatment of various medical conditions due to their selective anabolic effects and reduced side effects compared to traditional anabolic steroids. However, their safety in recreational use is questionable due to the lack of regulatory approval, potential for misuse, and insufficient data on long-term effects. Further research is needed to fully understand the safety profile of SARMs and to establish their role in clinical practice.

Is SARMs (Selective Androgen Receptor Modulators) safe?

Summary

Consensus Meter

Introduction

Key Insights from Research Papers

Conclusion

Sources and full results

Selective Androgen Receptor Modulators: Current Knowledge and Clinical Applications.

SARMs show potential for safe use in treating cancer-related cachexia, benign prostatic hyperplasia, hypogonadism, breast cancer, and prostate cancer.

Therapeutic potential of the SARMs: revisiting the androgen receptor for drug discovery

SARMs show potential as therapeutic agents for various diseases by maximizing positive attributes of steroidal androgens while minimizing negative effects, offering potential in muscle wasting associated with burns, cancer, end-stage renal disease, osteoporosis, frailty, and hypogonadism.

Selective Androgen Receptor Modulators as Function Promoting Therapies.

SARMs are used for various indications, including osteoporosis, anemia, male contraception, male hypogonadism, and wound healing, without causing prostate hypertrophy, secondary sex characteristics, or accelerating prostate cancer development.

Considerations, possible contraindications, and potential mechanisms for deleterious effect in recreational and athletic use of selective androgen receptor modulators (SARMs) in lieu of anabolic androgenic steroids: A narrative review

SARMs may not be a safer alternative to anabolic androgenic steroids due to potential contraindications and deleterious effects, and their use across various demographics remains controversial.

Selective androgen receptor modulators: the future of androgen therapy?

SARMs show potential as viable alternatives to current androgen therapies for various conditions, with few side effects and excellent oral and transdermal bioavailability.

Development of selective androgen receptor modulators (SARMs)

SARMs offer a promising treatment for various diseases by selectively activating androgen receptors in target tissues, with reduced side-effects.

SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMs) IN THE CONTEXT OF DOPING

SARMs are anabolic substances with potential health risks, and their use by athletes and bodybuilders is illegal due to their availability from uncertain sources and unclear pharmacotoxicological profile.

Systematic Review of Safety of Selective Androgen Receptor Modulators in Healthy Adults: Implications for Recreational Users

Recreational SARM use is strongly discouraged due to the risks of drug-induced liver injury, rhabdomyolysis, and tendon rupture.

Selective androgen receptor modulators as function promoting therapies

SARMs show promise as a new class of function-promoting anabolic therapies for aging, chronic disease, frailty, cancer cachexia, and osteoporosis without adversely affecting prostate and cardiovascular outcomes.

Selective Androgen Receptor Modulators (SARMs) in Sports: A Review

SARMs show promise for improving treatment processes for various diseases, but are prohibited by WADA due to potential doping and side effects.

Try another search