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These studies suggest that zinc and selenium are essential for immune function, metabolic rate, cognitive performance, and overall health, with deficiencies being common in various populations and supplementation improving health outcomes in both humans and animals.
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Selenium is an essential micronutrient with significant antioxidant properties. In the Spanish population, cereals and grains are the primary sources of selenium intake. However, in rural Tibetan diets, staple grains like tsampa and flour often fall below the selenium threshold, contributing only 15% to the recommended nutrient intake (RNI). Selenium-enriched foods, such as selenium-enriched mushroom powder, have shown promise in enhancing intestinal health and growth performance in post-weaned pigs, suggesting potential benefits for human diets as well.
Zinc is crucial for numerous bodily functions, including immune response and enzyme activity. Meat and meat products are the main sources of zinc in the Spanish diet. However, in Tibetan rural diets, staple grains contribute significantly to zinc intake, accounting for 43.5% of the RNI. Zinc-enriched foods, such as spirulina, have been shown to improve growth performance and antioxidant status in heat-stressed rabbits, indicating their potential as a dietary supplement.
Both selenium and zinc play vital roles in maintaining an optimal immune response. Selenium is necessary for the proper functioning of various immune cells, including neutrophils and T lymphocytes, and has been linked to reduced cancer risk and improved resistance to infections. Zinc is essential for enzyme function and immune responses, with supplementation shown to restore immune function and reduce infection rates in aging populations.
Adequate intake of selenium and zinc is associated with better cognitive performance. A study using data from the National Health and Nutrition Examination Survey (NHANES) found that higher intakes of these micronutrients were inversely associated with low cognitive performance in older adults. This suggests that maintaining sufficient levels of selenium and zinc could be beneficial for cognitive health.
Selenium and zinc co-supplementation has been shown to improve resting metabolic rate (RMR) and functional capacity in overweight and obese individuals on a hypocaloric diet. Additionally, these micronutrients have been found to alleviate insulin resistance and hepatic endoplasmic reticulum stress in gestational diabetes models, highlighting their role in metabolic health.
Despite their importance, deficiencies in selenium and zinc are common. In the Spanish ANIBES study, a significant portion of the population did not meet the recommended intakes for these micronutrients, with 25% deficient in selenium and 83% in zinc. Similarly, high rates of selenium and zinc deficiencies were observed in HIV-infected individuals, which were associated with adverse metabolic and inflammatory outcomes.
To combat these deficiencies, dietary diversification and the inclusion of selenium and zinc-enriched foods are recommended. For instance, adjusting grain consumption patterns and incorporating exogenous grains can improve selenium and zinc nutrition in rural Tibetan populations. Additionally, selenium-enriched mushroom powder and zinc-enriched spirulina have shown potential in enhancing nutritional status and health outcomes in animal studies, suggesting their applicability in human diets .
Selenium and zinc are essential micronutrients with significant health benefits, including antioxidant, immune, cognitive, and metabolic functions. Despite their importance, deficiencies are prevalent, necessitating dietary strategies to enhance intake. Incorporating selenium and zinc-rich foods, such as cereals, grains, meat products, and enriched supplements, can help address these deficiencies and improve overall health.
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