Selenium supplementation was safe but showed no benefit in preventing second primary tumors in patients with resected stage I non-small-cell lung cancer.

Randomized, double-blind, placebo-controlled, phase III chemoprevention trial of selenium supplementation in patients with resected stage I non-small-cell lung cancer: ECOG 5597.

The safe upper limit of selenium in drinking water should be reduced to 1 g/l due to potential health risks at lower levels than previously thought.

The need for a reassessment of the safe upper limit of selenium in drinking water.

Current evidence is insufficient to support a protective role for selenium in cardiovascular prevention, and high selenium intake may increase the risk of diabetes and hypercholesterolemia.

Selenium intake and cardiovascular risk: what is new?

High selenium levels in meat, eggs, poultry, and seafood are essential for human health, but supplementation for prevention of cardiovascular, hepatopathies, or cancer diseases is ambiguous and may increase toxicity risk.

Developmental selenium exposure and health risk in daily foodstuffs: A systematic review and meta-analysis.

Recent studies suggest selenium overexposure may be linked to type 2 diabetes, high-grade prostate cancer, and neurodegenerative diseases.

Environmental Selenium and Human Health: an Update

Organic selenium is safer than inorganic selenium and is recommended for those in selenium-deficient areas, while selenium-rich foods are the safest and best recommendation for those in selenium-deficient areas.

Selenium transformation and selenium-rich foods

Chronic low-level selenium overexposure is associated with an increased risk of amyotrophic lateral sclerosis, highlighting the need for further research on its neurotoxic effects.

Selenium neurotoxicity in humans: bridging laboratory and epidemiologic studies.

Selenium may reduce lung cancer risk in individuals with lower selenium levels, but should not be used as a general strategy for prevention.

Selenium and Lung Cancer: A Systematic Review and Meta Analysis

Selenium supplements should be taken at 200 micrograms per day for an adult of average weight, based on a typical American diet.

Nutritional Selenium Supplements: Product Types, Quality, and Safety

Low dose selenium nanoparticles and sodium selenite both induce similar dose-dependent changes in metabolite patterns in rats, potentially reflecting altered fatty acid and protein metabolism.

Effects of 14-day oral low dose selenium nanoparticles and selenite in rat—as determined by metabolite pattern determination

This study developed a method to evaluate selenium in dietary supplements using elemental speciation, revealing discrepancies between labeled ingredients and detected species, highlighting the need for accurate label claims.

Evaluation of selenium in dietary supplements using elemental speciation.

Higher selenium exposure is associated with lower cancer incidence and mortality, but no clear evidence exists for its effectiveness in cancer prevention through supplementation.

Selenium for preventing cancer.

Selenium supplementation was safe but showed no significant benefit over placebo in resected stage I non-small cell lung cancer patients.

A phase III, intergroup, randomized, double-blind, chemoprevention trial of selenium (Se) supplementation in resected stage I non-small cell lung cancer (NSCLC).

Selenium supplementation is a safe and effective method to enhance dietary selenium intake, with yeast being a safe and natural source.

Selenium: Significance, and outlook for supplementation.

Selenium is essential for human health in trace amounts, supporting antioxidant defense systems, thyroid hormone metabolism, reproductive functions, and neuroprotective effects, with excess posing risks to neurological functions and type-2 diabetes.

Biological Activity of Selenium and Its Impact on Human Health

Nano-Se is a potential chemopreventive agent with reduced selenium toxicity, offering equal antioxidant benefits as Se-methylselenocysteine but with lower toxicity.

Elemental selenium at nano size (Nano-Se) as a potential chemopreventive agent with reduced risk of selenium toxicity: comparison with se-methylselenocysteine in mice.

In Enshi County, China, safe utilization of selenium-rich land resources is crucial for local agricultural development and ecological sustainability, with a risk screening value of 0.98 g/g for cadmium in soil.

Safe utilization and zoning on natural selenium-rich land resources: a case study of the typical area in Enshi County, China

Low doses of selenium protect plants from abiotic stresses and can help overcome se deficiency and toxicity, but excessive selenium intake can cause toxicity.

An Overview of Selenium Uptake, Metabolism, and Toxicity in Plants

Adequate selenium intake and supplementation may improve prognosis and reduce the risk of developing various diseases, but excessive levels may have adverse effects.

The Role of Selenium in Pathologies: An Updated Review

Higher selenium levels are associated with fewer physical function limitations in older adults, including grip strength, mobility, and agility.

Selenium and impaired physical function in US and Spanish older adults

Some studies suggest selenium is safe in certain contexts and necessary for health, while other studies highlight potential risks such as increased diabetes, cancer, and neurodegenerative diseases with overexposure.