9 papers analyzed
These studies suggest that senolytics have potential in treating age-related diseases and improving health, but concerns about safety, such as off-target cell death and limited therapeutic index, indicate a need for more refined strategies for safe human use.
Senolytics are a class of drugs designed to target and eliminate senescent cells, which are cells that have stopped dividing and contribute to aging and age-related diseases. These drugs have shown promise in preclinical studies for extending health span and treating age-related diseases.
Key Insights from Research Papers:
Conclusion:
Senolytics present a promising avenue for extending health span and treating a range of age-related diseases by targeting senescent cells. While preclinical studies have shown various benefits, including improved physical function and potential cardiovascular improvements, concerns about their safety, particularly regarding off-target effects, remain. The efficacy and safety of senolytics in humans are still under investigation, with early clinical trials suggesting potential benefits but also emphasizing the need for further research to refine these therapies for safe and effective use.
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