Serum iron normal range

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Normal Range of Serum Iron: Insights from Research

Serum Iron Normal Range in Males and Females

The normal range of serum iron varies slightly between males and females. According to a study, the normal range for females is between 120-200 µg/100 ml, with an average of 160 µg/100 ml, while for males, it is between 125-238 µg/100 ml, with an average of 182 µg/100 ml . Another study supports these findings, indicating that the mean serum iron concentration is 138.3 ± 32.9 µg/100 ml, with no significant difference between sexes .

Variability in Serum Iron Measurements

Serum iron levels can show variability due to several factors, including the time of day the sample is collected and the specific population being studied. For instance, a study highlighted that serum iron levels measured in the morning (between 8:45 am and 9:15 am) showed consistent results . However, another study pointed out that different laboratories and patient populations might yield different normal ranges, emphasizing the importance of standardizing the conditions under which serum iron is measured .

Elevated Serum Iron Levels

Elevated serum iron levels, defined as 200 µg/100 ml or higher, were observed in a small percentage of healthy individuals. One study found that 6% of 500 healthy people had elevated serum iron levels, and further investigation revealed a high incidence of abnormal liver function tests among these individuals . Similarly, another study reported that 3.5% of 3,699 blood donors had serum iron levels of 200 µg/100 ml or higher .

Serum Ferritin as an Indicator of Iron Stores

Serum ferritin is another important marker used to assess iron stores in the body. Normal serum ferritin levels differ between males and females, with mean levels of 69 ng/ml in men and 35 ng/ml in women . Ferritin levels below 10 ng/ml are typically associated with iron deficiency . Additionally, serum ferritin levels can also act as an inflammatory biomarker, with elevated levels indicating potential inflammation or disease severity .

Conclusion

The normal range of serum iron is generally between 120-200 µg/100 ml for females and 125-238 µg/100 ml for males. Variability in measurements can occur due to different laboratory methods and sample collection times. Elevated serum iron levels are relatively rare but can indicate underlying health issues. Serum ferritin is a valuable marker for assessing iron stores and can also reflect inflammatory states. Understanding these ranges and their implications is crucial for accurate diagnosis and management of iron-related conditions.

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Most relevant research papers on this topic

Serum iron determination.

This sensitive, reproducible method for serum iron determination using isoamyl alcohol and ferrous complex provides accurate results in the normal range for females and males.

1956·

26citations

·G. Kingsley et al.

Clinical chemistry·

DOI

Normal Blood Iron Values

Normal blood iron values are not uniformly high or low, but rather a range that is less than 1% prevalence of abnormal values in a population.

1974·

0citations

·G. Haven

DOI

Serum iron, total iron-binding capacity, and percentage saturation in normal subjects

Serum iron, total iron-binding capacity, and siderophilin saturation are similar in both sexes and normally distributed, with no significant correlation with age in either males or females.

1968·

12citations

·R. Sinniah et al.

Journal of Clinical Pathology·

DOI

Serum iron levels in ostensibly normal people.

Elevated serum iron levels in 6% of supposedly healthy individuals may be linked to abnormal liver function tests and may not be due to a specific cause.

1974·

21citations

·W. Crosby et al.

JAMA·

DOI

Ferritin in the Serum of Normal Subjects and Patients with Iron Deficiency and Iron Overload

Ferritin levels in serum are a quantitative measure of storage iron in normal subjects and those with iron deficiency or overload.

Highly Cited

1972·

504citations

·A. Jacobs et al.

British Medical Journal·

DOI

SERUM IRON IN PSYCHIATRIC PATIENTS AND NORMAL CONTROLS *

Serum iron levels in psychiatric patients can be slightly above normal, particularly in those with alcohol or drug abuse, but often return to normal or sub-normal levels after a few days.

1968·

0citations

·O. Rafaelsen et al.

Acta Psychiatrica Scandinavica·

DOI

Ferritin in serum: diagnosis of iron deficiency and iron overload in infants and children.

Serum ferritin is a useful tool for evaluating iron status in infants and children, reflecting iron stores during normal development and aiding in the diagnosis of iron deficiency and iron overload.

Highly Cited

1974·

349citations

·M. Siimes et al.

Blood·

DOI

Serum ferritin as a measure of iron stores in normal subjects.

Serum ferritin is a useful tool for assessing and monitoring iron stores in normal individuals, with a high correlation to radioiron absorption measurements.

Highly Cited

1974·

592citations

·J. Cook et al.

The American journal of clinical nutrition·

DOI

Direct determination and binding capacity of serum iron.

The modified direct procedure for measuring serum iron levels and unsaturated iron-binding capacities provides a more accurate assessment of iron status in patients.

In Vitro Study

1961·

40citations

·A. Levy et al.

Clinical chemistry·

DOI

Optimal Serum Ferritin Level Range: iron status measure and inflammatory biomarker

Optimal serum ferritin levels for cardiovascular mortality reduction range from 20-100 ng/mL, with levels above 194 ng/mL associated with all-cause mortality.

2021·

53citations

·R. Depalma et al.

Metallomics·

DOI

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